Klotho protein: Its role in aging and central nervous system pathology
- Authors: Boksha I.S.1,2, Prokhorova T.A.1, Savushkina O.K.1, Tereshkina E.B.1
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Affiliations:
- Mental Health Research Center
- Gamaleya Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
- Issue: Vol 82, No 9 (2017)
- Pages: 990-1005
- Section: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/151463
- DOI: https://doi.org/10.1134/S0006297917090024
- ID: 151463
Cite item
Abstract
This review is devoted to Klotho protein and recent evidences for its functions in the brain. Information on transcriptional regulation of the klotho gene and posttranslational modifications of the protein resulting in multiple forms of Klotho is reviewed. Evidence is summarized that Klotho regulates the activity of protein factors, enzymes, and receptors, including data suggesting the importance of its glycosidase activity. Effects of Klotho on components of the glutamatergic neurotransmitter system, signal cascades involving protein kinases and protein phosphorylation, as well as oligodendrocyte differentiation and myelination are discussed. A possible contribution is proposed for Klotho levels in the development of central nervous system pathologies including mental disorders.
Keywords
About the authors
I. S. Boksha
Mental Health Research Center; Gamaleya Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Author for correspondence.
Email: boksha_irina@mail.ru
Russian Federation, Moscow, 115522; Moscow, 123098
T. A. Prokhorova
Mental Health Research Center
Email: boksha_irina@mail.ru
Russian Federation, Moscow, 115522
O. K. Savushkina
Mental Health Research Center
Email: boksha_irina@mail.ru
Russian Federation, Moscow, 115522
E. B. Tereshkina
Mental Health Research Center
Email: boksha_irina@mail.ru
Russian Federation, Moscow, 115522