DNA import into mitochondria
- 作者: Konstantinov Y.M.1,2, Dietrich A.3, Weber-Lotfi F.3, Ibrahim N.3, Klimenko E.S.1, Tarasenko V.I.1, Bolotova T.A.1, Koulintchenko M.V.1,3
- 
							隶属关系: 
							- Siberian Institute of Plant Physiology and Biochemistry
- Irkutsk State University
- Institut de Biologie Moléculaire des Plantes du CNRS
 
- 期: 卷 81, 编号 10 (2016)
- 页面: 1044-1056
- 栏目: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/151023
- DOI: https://doi.org/10.1134/S0006297916100035
- ID: 151023
如何引用文章
详细
In recent decades, it has become evident that the condition for normal functioning of mitochondria in higher eukaryotes is the presence of membrane transport systems of macromolecules (proteins and nucleic acids). Natural competence of the mitochondria in plants, animals, and yeasts to actively uptake DNA may be directly related to horizontal gene transfer into these organelles occurring at much higher rate compared to the nuclear and chloroplast genomes. However, in contrast with import of proteins and tRNAs, little is known about the biological role and molecular mechanism underlying import of DNA into eukaryotic mitochondria. In this review, we discuss current state of investigations in this area, particularly specificity of DNA import into mitochondria and its features in plants, animals, and yeasts; a tentative mechanism of DNA import across the mitochondrial outer and inner membranes; experimental data evidencing several existing, but not yet fully understood mechanisms of DNA transfer into mitochondria. Currently available data regarding transport of informational macromolecules (DNA, RNA, and proteins) into the mitochondria do not rule out that the mechanism of protein and tRNA import as well as tRNA and DNA import into the mitochondria may partially overlap.
作者简介
Yu. Konstantinov
Siberian Institute of Plant Physiology and Biochemistry; Irkutsk State University
							编辑信件的主要联系方式.
							Email: yukon@sifibr.irk.ru
				                					                																			                												                	俄罗斯联邦, 							Irkutsk, 664033; Irkutsk, 664003						
A. Dietrich
Institut de Biologie Moléculaire des Plantes du CNRS
														Email: yukon@sifibr.irk.ru
				                					                																			                												                	法国, 							Strasbourg, 67084						
F. Weber-Lotfi
Institut de Biologie Moléculaire des Plantes du CNRS
														Email: yukon@sifibr.irk.ru
				                					                																			                												                	法国, 							Strasbourg, 67084						
N. Ibrahim
Institut de Biologie Moléculaire des Plantes du CNRS
														Email: yukon@sifibr.irk.ru
				                					                																			                												                	法国, 							Strasbourg, 67084						
E. Klimenko
Siberian Institute of Plant Physiology and Biochemistry
														Email: yukon@sifibr.irk.ru
				                					                																			                												                	俄罗斯联邦, 							Irkutsk, 664033						
V. Tarasenko
Siberian Institute of Plant Physiology and Biochemistry
														Email: yukon@sifibr.irk.ru
				                					                																			                												                	俄罗斯联邦, 							Irkutsk, 664033						
T. Bolotova
Siberian Institute of Plant Physiology and Biochemistry
														Email: yukon@sifibr.irk.ru
				                					                																			                												                	俄罗斯联邦, 							Irkutsk, 664033						
M. Koulintchenko
Siberian Institute of Plant Physiology and Biochemistry; Institut de Biologie Moléculaire des Plantes du CNRS
														Email: yukon@sifibr.irk.ru
				                					                																			                												                	俄罗斯联邦, 							Irkutsk, 664033; Strasbourg, 67084						
补充文件
 
				
			 
						 
						 
					 
						 
						 
				 
  
  
  
  
  电邮这篇文章
			电邮这篇文章  开放存取
		                                开放存取 ##reader.subscriptionAccessGranted##
						##reader.subscriptionAccessGranted## 订阅存取
		                                		                                        订阅存取
		                                					