Functional role of carbohydrate residues in human immunoglobulin G and therapeutic monoclonal antibodies
- Authors: Dorokhov Y.L.1,2, Sheshukova E.V.1, Kosobokova E.N.1, Shindyapina A.V.1,2, Kosorukov V.S.1, Komarova T.V.1,2
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Affiliations:
- Vavilov Institute of General Genetics
- Belozersky Institute of Physico-Chemical Biology
- Issue: Vol 81, No 8 (2016)
- Pages: 835-857
- Section: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/150973
- DOI: https://doi.org/10.1134/S0006297916080058
- ID: 150973
Cite item
Abstract
Therapeutic monoclonal antibodies (TMA) provide an important means for treating diseases that were previously considered untreatable. Currently more than 40 full-size TMAs created primarily based on immunoglobulin G1 are widely used for treating various illnesses. Glycosylation of TMA is among other numerous factors that affect their biological activity, effector functions, immunogenicity, and half-life in the patient’s serum. The importance of carbohydrate residues for activity of human serum immunoglobulin and TMA produced in animal cells is considered in this review, with emphasis given to N-glycosylation of the Fc fragment of the antibody.
About the authors
Y. L. Dorokhov
Vavilov Institute of General Genetics; Belozersky Institute of Physico-Chemical Biology
Author for correspondence.
Email: dorokhov@genebee.msu.su
Russian Federation, Moscow, 119991; Moscow, 119991
E. V. Sheshukova
Vavilov Institute of General Genetics
Email: dorokhov@genebee.msu.su
Russian Federation, Moscow, 119991
E. N. Kosobokova
Vavilov Institute of General Genetics
Email: dorokhov@genebee.msu.su
Russian Federation, Moscow, 119991
A. V. Shindyapina
Vavilov Institute of General Genetics; Belozersky Institute of Physico-Chemical Biology
Email: dorokhov@genebee.msu.su
Russian Federation, Moscow, 119991; Moscow, 119991
V. S. Kosorukov
Vavilov Institute of General Genetics
Email: dorokhov@genebee.msu.su
Russian Federation, Moscow, 119991
T. V. Komarova
Vavilov Institute of General Genetics; Belozersky Institute of Physico-Chemical Biology
Email: dorokhov@genebee.msu.su
Russian Federation, Moscow, 119991; Moscow, 119991