Email this article Antimicrobial Peptides in Health and Disease (Review)
- Authors: Konovalova M.V.1, Zubareva A.A.2, Lutsenko G.V.1, Svirshchevskaya E.V.1
-
Affiliations:
- Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
- Fundamentals of Biotechnology Institute of Bioengineering, Federal Research Center
- Issue: Vol 54, No 3 (2018)
- Pages: 238-244
- Section: Article
- URL: https://journals.rcsi.science/0003-6838/article/view/152469
- DOI: https://doi.org/10.1134/S0003683818030079
- ID: 152469
Cite item
Open Access
Access granted
Subscription Access
Abstract
The review describes the latest data on the role of antimicrobial peptides (AMPs) in health and disease, as well as their structure and mechanisms of action. AMPs mediate protection by both direct lysis of bacteria and also by regulation of inflammation and chemotaxis, thus demonstrating immunomodulatory properties. A large amount of data shows that AMPs play an important role in the pathogenesis of multiple chronic diseases with genetic predisposition, such as atopic dermatitis, rosacea, and scleroderma.
About the authors
M. V. Konovalova
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Author for correspondence.
Email: mariya.v.konovalova@gmail.com
Russian Federation, Moscow, 117997
A. A. Zubareva
Fundamentals of Biotechnology Institute of Bioengineering, Federal Research Center
Email: mariya.v.konovalova@gmail.com
Russian Federation, Moscow, 119071
G. V. Lutsenko
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: mariya.v.konovalova@gmail.com
Russian Federation, Moscow, 117997
E. V. Svirshchevskaya
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: mariya.v.konovalova@gmail.com
Russian Federation, Moscow, 117997
Supplementary files
