Antibacterial effect of peptide conjugates with a quaternized chitosan derivative and its estimation by the method of atomic force microscopy


Citar

Texto integral

Acesso aberto Acesso aberto
Acesso é fechado Acesso está concedido
Acesso é fechado Somente assinantes

Resumo

We obtained a number of conjugates based on a quaternized chitosan derivative and antimicrobial peptides (melittin and warnerin) crosslinked by microbial transglutaminase. We determined the optimal conditions for the synthesis (30 minutes, with a mole ratio of peptides and chitosan derivative of 1.4: 100) and studied the antibacterial properties of obtained conjugates. The antibacterial effect of the conjugates was found to be greater than that of their components. The antibacterial activity of the conjugates was determined by the double-dilution method and by atomic force microscopy.

Sobre autores

Yu. Chudinova

Institute of Bioengineering

Email: varlamov@biengi.ac.ru
Rússia, Moscow, 119071

B. Shagdarova

Institute of Bioengineering

Email: varlamov@biengi.ac.ru
Rússia, Moscow, 119071

A. Il’ina

Institute of Bioengineering

Email: varlamov@biengi.ac.ru
Rússia, Moscow, 119071

V. Varlamov

Institute of Bioengineering

Autor responsável pela correspondência
Email: varlamov@biengi.ac.ru
Rússia, Moscow, 119071

Arquivos suplementares

Arquivos suplementares
Ação
1. JATS XML

Declaração de direitos autorais © Pleiades Publishing, Inc., 2016