Email this article Modified Antiproteinase Hemosorbent
- Authors: Valuev I.L.1, Valuev L.I.1, Vanchugova L.V.1, Obydennova I.V.1
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Affiliations:
- Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences
- Issue: Vol 55, No 1 (2019)
- Pages: 21-24
- Section: Article
- URL: https://journals.rcsi.science/0003-6838/article/view/152762
- DOI: https://doi.org/10.1134/S0003683819010174
- ID: 152762
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Abstract
A method to increase the thromboresistance of the biospecific antiproteinase hemosorbent was suggested based on simultaneous immobilization of duck egg ovomucoid and blood anticoagulant—heparin or hirudin—in the bulk of polyacrylamide hydrogel. It was demonstrated that modification of the hemosorbent with hirudin resulted in a significant increase of its compatibility with blood with simultaneous preservation of high capacity with regards to serine proteinases.
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About the authors
I. L. Valuev
Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences
Author for correspondence.
Email: valuev@ips.ac.ru
Russian Federation, Moscow, 119991
L. I. Valuev
Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences
Email: valuev@ips.ac.ru
Russian Federation, Moscow, 119991
L. V. Vanchugova
Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences
Email: valuev@ips.ac.ru
Russian Federation, Moscow, 119991
I. V. Obydennova
Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences
Email: valuev@ips.ac.ru
Russian Federation, Moscow, 119991
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