Analysis of Serum Albumin Isoforms Belonging to Membranotropic Homeostatic Tissue-Specific Bioregulators Isolated from Different Mammalian Tissues

Abstract

Membranotropic homeostatic tissue-specific bioregulators (MHTBs) isolated from various tissues of cattle (Bos taurus) and rats (Rattus norvegicus) basically comprise peptide-protein complexes consisting of low-molecular polypeptides (1–6 kDa) and serum albumin represented in NCBI databases by three isoforms for each of the species: gi|1351907, gi|367460260, gi|74267962 and gi|124028612, gi|158138568, and gi|55628, respectively. The sites of amino acid substitutions in the primary sequence of these albumins are determined to be located in the second and third domains of the albumin molecules. The polypeptides in the MHTB composition are the proteolysis products of enzymes and adhesive proteins.