Email this article Enzymatic biocatalysis in chemical synthesis of pharmaceuticals (Review)
- Authors: Bezborodov A.M.1, Zagustina N.A.1
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Affiliations:
- A.N. Bach Institute of Biochemistry, Fundamentals of Biotechnology Federal Research Center
- Issue: Vol 52, No 3 (2016)
- Pages: 237-249
- Section: Article
- URL: https://journals.rcsi.science/0003-6838/article/view/151900
- DOI: https://doi.org/10.1134/S0003683816030030
- ID: 151900
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Abstract
In this review we summarize the available research on enzymatic biocatalysis in the chemical synthesis of drugs. We focus on oxydoreductsases, particularly ketoreductases, that are widely used in biotechnological processes: alpha- and omega-transaminases, lipases, nitrile hydrolases, and aldolases. The potential for the extended use of novel enzymes produced via bioengineering is discussed.
About the authors
A. M. Bezborodov
A.N. Bach Institute of Biochemistry, Fundamentals of Biotechnology Federal Research Center
Email: zagust@inbi.ras.ru
Russian Federation, Moscow, 119071
N. A. Zagustina
A.N. Bach Institute of Biochemistry, Fundamentals of Biotechnology Federal Research Center
Author for correspondence.
Email: zagust@inbi.ras.ru
Russian Federation, Moscow, 119071
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