Opportunities to predict effectiveness of antisecretory therapy in patients with gastroesophageal reflux disease

To determine the factors that affect the effectiveness of gastroesophageal reflux disease therapy, a correlation analysis was performed that included the international GERD questionnaire, the hospital anxiety and depression score (HADS), and data on the polymorphism of cytochrome P450 2C19 in 136 patients with different variants gastroesophageal reflux disease (GERD): reflux esophagitis (RE), non-erosive reflux disease (NERD) and reflux hypersensitivity (RH). The presence of a strong negative relationship between the favorable outcome of PPI therapy and the GERD score was demonstrated after 4 weeks of therapy in the RE, NERD and RH groups (p < 0.001). When analyzing the relationship between the HADS scale and the effectiveness of therapy, a strong negative correlation was found only in the RE group (p < 0.001), the fact that the metabolic rate of the PPI moderately correlated with the favorable outcome of therapy in the RH and NERD groups (p < 0.05).