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发表评论 H. pylori根除疗法：在胃粘膜萎缩性改变的情况下将阿莫西林转运至H. pylori定植部位
- 作者: Sablina A.1, Sablin O.1, Andreeva J.2, Rodionov G.1, Shantyr I.1, Ushal I.1, Samusenko I.1
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隶属关系:
- Nikiforov Russian Center of Emergency and Radiation Medicine
- Pavlov Institute of Physiology
- 期: 卷 13, 编号 2 (2021)
- 页面: 57-66
- 栏目: Original research
- URL: https://journals.rcsi.science/vszgmu/article/view/70280
- DOI: https://doi.org/10.17816/mechnikov70280
- ID: 70280
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详细
这项工作的目的是确定阿莫西林的全身转运特征，阿莫西林是根除治疗方案中最常见的抗生素H. pylori进入有萎缩性胃炎的胃腔。
材料与方法。采用胃粘膜洗涤法对萎缩性胃炎模型及对照组大鼠胃腔中阿莫西林的系统转运进行了研究静脉注射药物后。阿莫西林从血流到胃腔的运输也被评估为萎缩性胃炎和非营养性胃炎患者通过鼻窦吸入胃液口服药物后的探头。用色谱质谱法测定了样品中的阿莫西林浓度。
结果。实验组大鼠经宏观检查发现胃粘膜充血及急性糜烂性改变，以及胃体外非活动性慢性胃炎和非活动性慢性体外萎缩性胃炎的显微特征。实验组大鼠胃粘膜冲洗中阿莫西林浓度在所有时间点（30、60、120、 240分钟用药后）均可靠（p<0.01）较高，而不是控制组的老鼠。患者胃液中阿莫西林的平均浓度在胃侧部萎缩时最低(p<0,01)。胃黏膜萎缩患者在吸入第180分钟时观察到阿莫西林在胃分泌物中的最大浓度，对于对照组的人-从第30分钟到第120分钟。胃黏膜萎缩患者在吸入第180分钟时观察到阿莫西林在胃分泌物中的最大浓度，对于对照组的人-从第30分钟到第120分钟。
结论。胃黏膜的急性糜烂性改变进入大鼠的胃腔，导致阿莫西林转运增加。患者中胃窦部的黏膜萎缩程度大于胃体，其特征是口服药物后阿莫西林从体循环到胃腔的转运减少。预测根除疗法的有效性时H. pylori慢性胃炎患者要考虑到胃黏膜萎缩的存在。
作者简介
Anastasiya Sablina
Nikiforov Russian Center of Emergency and Radiation Medicine
编辑信件的主要联系方式.
Email: a.o.sablina@mail.ru
ORCID iD: 0000-0002-0337-453X
SPIN 代码: 1044-8392
Scopus 作者 ID: 57216203494
MD, PhD student
俄罗斯联邦, 4/2 Academica Lebedeva str., Saint Petersburg, 194044Oleg Sablin
Nikiforov Russian Center of Emergency and Radiation Medicine
Email: gastroleg@yandex.ru
ORCID iD: 0000-0002-2597-1220
SPIN 代码: 5446-2329
Scopus 作者 ID: 6508192177
Researcher ID: U-1854-2017
MD, Dr. Sci. (Med.), Professor
俄罗斯联邦, 4/2 Academica Lebedeva str., Saint Petersburg, 194044Julia Andreeva
Pavlov Institute of Physiology
Email: jandreeva@mail.ru
ORCID iD: 0000-0002-7360-9306
SPIN 代码: 5122-4026
Scopus 作者 ID: 42960935800
Researcher ID: AAO-9573-2021
Cand. Sci. (Biol.)
俄罗斯联邦, Saint PetersburgGennadii Rodionov
Nikiforov Russian Center of Emergency and Radiation Medicine
Email: rodgengeor@yandex.ru
ORCID iD: 0000-0001-6237-7848
SPIN 代码: 6471-3933
Scopus 作者 ID: 57220177362
Researcher ID: AAQ-5773-2021
MD, Dr. Sci. (Med.), Assistant Professor
俄罗斯联邦, 4/2 Academica Lebedeva str., Saint Petersburg, 194044I. Shantyr
Nikiforov Russian Center of Emergency and Radiation Medicine
Email: shantyr@arcerm.spb.ru
ORCID iD: 0000-0003-1840-5770
SPIN 代码: 8038-2999
Scopus 作者 ID: 57216182544
MD, Dr. Sci. (Med.), Professor
俄罗斯联邦, 4/2 Academica Lebedeva str., Saint Petersburg, 194044Inna Ushal
Nikiforov Russian Center of Emergency and Radiation Medicine
Email: innaushal@mail.ru
ORCID iD: 0000-0001-5857-3627
SPIN 代码: 4726-8832
Scopus 作者 ID: 23111545700
Cand. Sci. (Biol.)
俄罗斯联邦, 4/2 Academica Lebedeva str., Saint Petersburg, 194044Igor Samusenko
Nikiforov Russian Center of Emergency and Radiation Medicine
Email: egors_2000@mail.ru
ORCID iD: 0000-0003-0622-3515
SPIN 代码: 6669-5602
Scopus 作者 ID: 14020322000
Cand. Sci. (Med.)
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