Shared pathological mechanisms of systemic lupus erythematosus and affective disorders
- 作者: Rukavishnikov G.1, Smirnova A.1, Neznanov N.1,2, Mazurov V.3, Mazo G.1
-
隶属关系:
- V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology
- I.P. Pavlov First Saint Petersburg State Medical University
- North-Western State Medical University named after I.I. Mechnikov
- 期: 卷 13, 编号 2 (2021)
- 页面: 5-14
- 栏目: Reviews
- URL: https://journals.rcsi.science/vszgmu/article/view/61262
- DOI: https://doi.org/10.17816/mechnikov61262
- ID: 61262
如何引用文章
详细
The high prevalence and variability of neurological and psychiatric symptoms in systemic lupus erythematosus has become the basis for emphasizing the special neuropsychiatric form of the disorder. Affective disorders (pathological changes in mood and anxiety) are the second most common neuropsychiatric manifestations in patients with systemic lupus erythematosus. However, the current nomenclature primarily focuses on the general clinical manifestations of affective disorders in neuropsychiatric form systemic lupus erythematosus, without evaluating the problems of their etiopathogenesis. Thereby, the aim of this review is the integration of information on the pathological mechanisms of depression and anxiety in patients with systemic lupus erythematosus. The available data on the biological aspects of the anxiety and depression in systemic lupus erythematosus indicate that the complex pathological models may be the best approach for studying, diagnosing, and treating comorbid pathology. The latter can be based on expanding the existing clinical categories, supplementing them with data on pathological mechanisms specific to particular sub-cohorts of patients. Such an approach can provide the specific and most effective preventive, diagnostic and therapeutic measures for each category of patients.
作者简介
Grigory Rukavishnikov
V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology
编辑信件的主要联系方式.
Email: grigory_v_r@mail.ru
ORCID iD: 0000-0002-5282-2036
MD, Cand. Sci. (Med.)
俄罗斯联邦, 3 Bekhtereva str., Saint Petersburg, 192019Anna Smirnova
V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology
Email: annakaraseva37@mail.ru
ORCID iD: 0000-0002-4703-0712
俄罗斯联邦, 3 Bekhtereva str., Saint Petersburg, 192019
Nikolay Neznanov
V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology; I.P. Pavlov First Saint Petersburg State Medical University
Email: spbinstb@bekhterev.ru
ORCID iD: 0000-0001-5618-4206
MD, Dr. Sci. (Med.), Professor
俄罗斯联邦, 3 Bekhtereva str., Saint Petersburg, 192019; Saint PetersburgVadim Mazurov
North-Western State Medical University named after I.I. Mechnikov
Email: maz.nwgmu@yandex.ru
ORCID iD: 0000-0002-0797-2051
SPIN 代码: 6823-5482
Scopus 作者 ID: 16936315400
Researcher ID: A-8944-2016
MD, Dr. Sci. (Med.), Professor, Honoured Science Worker, Academician of the RAS
俄罗斯联邦, 41 Kirochnaya str., Saint Petersburg, 191015Galina Mazo
V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology
Email: galina-mazo@yandex.ru
ORCID iD: 0000-0001-7036-5927
MD, Dr. Sci. (Med.)
俄罗斯联邦, 3 Bekhtereva str., Saint Petersburg, 192019参考
- Postal M, Lapa AT, Sinicato NA, et al. Depressive symptoms are associated with tumor necrosis factor alpha in systemic lupus erythematosus. J Neuroinflammation. 2016;13:5. doi: 10.1186/s12974-015-0471-9
- Zhang L, Fu T, Yin R, et al. Prevalence of depression and anxiety in systemic lupus erythematosus: a systematic review and meta-analysis. BMC Psychiatry. 2017;17(1):70. doi: 10.1186/s12888-017-1234-1
- Primer on the Rheumatic Diseases. J.H. Klippel, J.H. Stone, L.J. Crofford, P.H. White (eds). Springer; 2008. doi: 10.1007/978-0-387-68566-3
- Hawro T, Krupińska-Kun M, Rabe-Jabłońska J, et al. Psychiatric disorders in patients with systemic lupus erythematosus: association of anxiety disorder with shorter disease duration. Rheumatol Int. 2011;31(10):1387–1391. doi: 10.1007/s00296-010-1689-6
- Kwan A, Katz P, Touma Z. The assessment of anxiety and depression and its associated factors in SLE. Curr Rheumatol Rev. 2019;15(2):90–98. doi: 10.2174/1573397114666180926101513
- Seawell AH, Danoff-Burg S. Body image and sexuality in women with and without systemic lupus erythematosus. Sex Roles. 2005;53(11):865–876. doi: 10.1007/s11199-005-8298-y
- Vivaldo JF, de Amorim JC, Julio PR, et al. Definition of NPSLE: Does the ACR nomenclature still hold? Front Med (Lausanne). 2018;5:138. doi: 10.3389/fmed.2018.00138
- Alsowaida N, Alrasheed M, Mayet A, et al. Medication adherence, depression and disease activity among patients with systemic lupus erythematosus. Lupus. 2018;27(2):327–332. doi: 10.1177/0961203317725585
- Palagini L, Mosca M, Tani C, et al. Depression and systemic lupus erythematosus: a systematic review. Lupus. 2013;22(5):409–416. doi: 10.1177/0961203313477227
- Xu J, Cheng YQ, Chen B, et al. Depression in systemic lupus erythematosus patients is associated with link-polymorphism but not methylation status of the 5HTT promoter region. Lupus. 2013;22(10):1001–1010. doi: 10.1177/0961203313498793
- Jeltsch-David H, Muller S. Neuropsychiatric systemic lupus erythematosus: pathogenesis and biomarkers. Nat Rev Neurol. 2014;10(10):579–596. doi: 10.1038/nrneurol.2014.148
- Dantzer R. Cytokine, sickness behavior, and depression. Immunol Allergy Clin North Am. 2009;29(2):247–264. doi: 10.1016/j.iac.2009.02.002
- Khairova RA, Machado-Vieira R, Du J, Manji HK. A potential role for pro-inflammatory cytokines in regulating synaptic plasticity in major depressive disorder. Int J Neuropsychopharmacol. 2009;12(4):561–578. doi: 10.1017/S1461145709009924
- Ménard C, Hodes GE, Russo SJ. Pathogenesis of depression: Insights from human and rodent studies. Neuroscience. 2016;321:138–162. doi: 10.1016/j.neuroscience.2015.05.053
- Krishnadas R, Cavanagh J. Depression: an inflammatory illness? J Neurol Neurosurg Psychiatry. 2012;83(5):495–502. doi: 10.1136/jnnp-2011-301779
- Himmerich H, Fulda S, Linseisen J, et al. Depression, comorbidities and the TNF-alpha system. Eur Psychiatry. 2008;23(6):421–429. doi: 10.1016/j.eurpsy.2008.03.013
- Berthold-Losleben M, Himmerich H. The TNF-alpha system: functional aspects in depression, narcolepsy and psychopharmacology. Curr Neuropharmacol. 2008;6(3):193–202. doi: 10.2174/157015908785777238
- Doczy EJ, Seroogy K, Harrison CR, Herman JP. Hypothalamo-pituitary-adrenocortical axis, glucocorticoids, and neurologic disease. Immunol Allergy Clin North Am. 2009;29(2):265–284. doi: 10.1016/j.iac.2009.02.003
- Black PH. Immune system-central nervous system interactions: effect and immunomodulatory consequences of immune system mediators on the brain. Antimicrob Agents Chemother. 1994;38(1):7–12. doi: 10.1128/AAC.38.1.7
- Vallieres L, Rivest S. Interleukin-6 is a needed proinflammatory cytokine in the prolonged neural activity and transcriptional activation of corticotropinreleasing factor during endotoxemia. Endocrinology. 1999;140(9):3890–3903. doi: 10.1210/endo.140.9.6983
- Chrousos GP. The hypothalamic-pituitary-adrenal axis and immunemediated inflammation. N Engl J Med. 1995;332(20):1351–1362. doi: 10.1056/NEJM199505183322008
- McCann SM, Lyson K, Karanth S, et al. Mechanism of action of cytokines to induce the pattern of pituitary hormone secretion in infection. Ann N Y Acad Sci. 1995;771:386–395. doi: 10.1111/j.1749-6632.1995.tb44697.x
- Dantzer R, Wollman E, Vitkovic L, Yirmiya R. Cytokines and depression: fortuitous or causative association? Mol Psychiatry. 1999;4(4):328–332. doi: 10.1038/sj.mp.4000572
- Dowlati Y, Herrmann N, Swardfager W, et al. A meta-analysis of cytokines in major depression. Biol Psychiatry. 2010;67(5):446–457. doi: 10.1016/j.biopsych.2009.09.033
- Zhu CB, Blakely RD, Hewlett WA. The proinflammatory cytokines interleukin-1beta and tumor necrosis factor-alpha activate serotonin transporters. Neuropsychopharmacology. 2006;31(10):2121–2131. doi: 10.1038/sj.npp.1301029
- Müller N, Schwarz MJ. Immunologische Aspekte bei depressiven Störungen [Immunological aspects of depressive disorders]. Nervenarzt. 2007;78(11):1261–1273. (In German). doi: 10.1007/s00115-007-2311-3
- Wichers M, Maes M. The psychoneuroimmuno-pathophysiology of cytokine-induced depression in humans. Int J Neuropsychopharmacol. 2002;5(4):375–388. doi: 10.1017/S1461145702003103
- Himmerich H, Fulda S, Linseisen J, et al. Depression, comorbidities and the TNF-alpha system. Eur Psychiatry. 2008;23(6):421–429. doi: 10.1016/j.eurpsy.2008.03.013
- Lang UE, Borgwardt S. Molecular mechanisms of depression: perspectives on new treatment strategies. Cell Physiol Biochem. 2013;31(6):761–777. doi: 10.1159/000350094
- Tisseverasinghe A, Peschken C, Hitchon C. Anxiety and mood disorders in systemic lupus erythematosus: current insights and future directions. Curr Rheumatol Rep. 2018;20(12):85. doi: 10.1007/s11926-018-0797-2
- Seth G, Sundaresh A, Mariaselvam CM, et al. Immunological biomarkers in neuropsychiatric systemic lupus erythematosus: a comparative cross-sectional study from a tertiary care center in South India. Lupus. 2020;29(4):413–420. doi: 10.1177/0961203320908940
- Figueiredo-Braga M, Cornaby C, Cortez A, et al. Depression and anxiety in systemic lupus erythematosus: The crosstalk between immunological, clinical, and psychosocial factors. Medicine (Baltimore). 2018;97(28):e11376. doi: 10.1097/MD.0000000000011376
- Zheng Q, Xu MJ, Cheng J, et al. Serum levels of brain-derived neurotrophic factor are associated with depressive symptoms in patients with systemic lupus erythematosus. Psychoneuroendocrinology. 2017;78:246–252. doi: 10.1016/j.psyneuen.2016.12.001
- Ikenouchi-Sugita A, Yoshimura R, Okamoto T, et al. Serum brain-derived neurotrophic factor levels as a novel biological marker for the activities of psychiatric symptoms in systemic lupus erythematosus. World J Biol Psychiatry. 2010;11(2):121–128. doi: 10.3109/15622970903521131
- Lahita RG, Bradlow HL, Kunkel HG, Fishman J. Alterations of estrogen metabolism in systemic lupus erythematosus. Arthritis Rheum. 1979;22(11):1195–1198. doi: 10.1002/art.1780221106
- Khan WA, Zaman GS, Alouffi S, Khan MWA. Depression and its related parameters increased the production of autoantibodies against 16α-hydroxyestrone-albumin complex in systemic lupus erythematosus. Int Immunopharmacol. 2019;71:215–223. doi: 10.1016/j.intimp.2019.03.036
- Weidler C, Härle P, Schedel J, et al. Patients with rheumatoid arthritis and systemic lupus erythematosus have increased renal excretion of mitogenic estrogens in relation to endogenous antiestrogens. J Rheumatol. 2004;31(3):489–494.
- Reichlin S. Prolactin and growth hormone secretion in stress. Adv Exp Med Biol. 1988;245:353–376. doi: 10.1007/978-1-4899-2064-5_28
- Dorshkind K, Horseman ND. The roles of prolactin, growth hormone, insulin-like growth factor-I, and thyroid hormones in lymphocyte development and function: insights from genetic models of hormone and hormone receptor deficiency. Endocr Rev. 2000;21(3):292–312. doi: 10.1210/edrv.21.3.0397
- Torner L, Toschi N, Pohlinger A, et al. Anxiolytic and anti-stress effects of brain prolactin: improved efficacy of antisense targeting of the prolactin receptor by molecular modeling. J Neurosci. 2001;21(9):3207–3214. doi: 10.1523/JNEUROSCI.21-09-03207.2001
- Torner L, Neumann ID. The brain prolactin system: involvement in stress response adaptations in lactation. Stress. 2002;5(4):249–257. doi: 10.1080/1025389021000048638
- Yu-Lee LY. Prolactin modulation of immune and inflammatory responses. Recent Prog Horm Res. 2002;57:435–455. doi: 10.1210/rp.57.1.435
- Cook CJ. Oxytocin and prolactin suppress cortisol responses to acute stress in both lactating and non-lactating sheep. J Dairy Res. 1997;64(3):327–339. doi: 10.1017/s0022029997002240
- Jara LJ, Medina G, Saavedra MA, et al. Prolactin has a pathogenic role in systemic lupus erythematosus. Immunol Res. 2017;65(2):512–523. doi: 10.1007/s12026-016-8891-x
- Gholamrezaei A, Bonakdar ZS, Mirbagher L, Hosseini N. Sleep disorders in systemic lupus erythematosus. Does vitamin D play a role? Lupus. 2014;23(10):1054–1058. doi: 10.1177/0961203314532563
- Katzav A, Solodeev I, Brodsky O, et al. Induction of autoimmune depression in mice by anti-ribosomal P antibodies via the limbic system. Arthritis Rheum. 2007;56(3):938–948. doi: 10.1002/art.22419