Causes and clinical symptoms of anaphylactic reactions in children: implementation into clinical practice of the first Pediatric Moscow Anaphylaxis Registry in the Russian Federation
- 作者: Pampura A.1,2, Esakova N.2, Zimin S.1, Кovtun E.1, Kara Y.1, Busova E.1, Bzhekshieva Z.1, Leonteva M.1, Vitkovskaya I.1, Gorev V.1
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隶属关系:
- Morozov Children's Municipal Clinical Hospital
- Veltischev Research and Clinical Institute for Pediatrics and Pediatric Surgery of the Pirogov Russian National Research Medical University of the Russian Ministry of Health
- 期: 卷 21, 编号 2 (2024)
- 页面: 203-215
- 栏目: Original studies
- URL: https://journals.rcsi.science/raj/article/view/260056
- DOI: https://doi.org/10.36691/RJA16907
- ID: 260056
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详细
BACKGROUND: For a long time in the Russian Federation, there was a problem of the lack of registry of anaphylaxis, as the most important tool for recording and monitoring this group of patients. Since 2022, the first Pediatric Moscow Anaphylaxis Registry has started working at the Morozov Children's Hospital.
AIM: Objectification and analysis of data from the Pediatric Moscow Anaphylaxis Registry to determine the frequency, causes and characteristics of anaphylaxis clinical symptoms among children of the Moscow region.
MATERIALS AND METHODS: The statistical analysis of the questionnaire data of the patient-oriented questionnaire of 69 children aged 0 to 18 years, who were prospectively included in the Register during emergency hospitalization due to anaphylaxis, was carried out.
RESULTS: The incidence of anaphylaxis among children hospitalized with acute allergic reactions from May 2022 to September 2023 was 5.8%. A higher percentage of anaphylaxis episodes (38%) were observed among adolescents aged 13–18 years, three patients developed anaphylaxis in the first year of life (minimum age 1 month). Boys (70%) prevailed among patients with anaphylaxis under the age of 13, and girls (56%) prevailed among adolescents aged 13–18 (p=0.042). In 75%, anaphylaxis developed at home. For patients of all age groups, food anaphylaxis was dominant (75–91%). Tree nuts were the most common suspected trigger of food anaphylaxis ― 35% of reactions, and confectionery products in 17% of cases. With anaphylaxis, 56% of children experienced symptoms from four or more organ systems, the most common symptoms were from the skin/mucous (94%), respiratory organs (78%) and laryngeal symptoms (64%). At the stage of emergency medical care, the frequency of diagnosis of anaphylaxis was 22%, and the administration of epinephrine was 54%. The frequency of epinephrine use among children under 3 years of age was lower compared to adolescents aged 13–18 years (25% vs 76%, p=0.003)
CONCLUSION: The data from the work of the first Pediatric Moscow Anaphylaxis Registry in the Russian Federation demonstrate a high incidence of anaphylaxis among patients with acute allergic reactions. More than 1/3 of anaphylactic reactions occur in adolescents aged 13–18 years, while anaphylaxis occurs even in the first month of life. Anaphylaxis most often develops at home, which dictates the special need for careful training of patients in the rules of elimination of the trigger. The dominant cause of anaphylaxis in children in the Russian Federation, regardless of age, are food allergens, tree nuts induce anaphylaxis in more than 1/3 of cases. The frequency of diagnosis of anaphylaxis at the stage of emergency medical care does not exceed 22%, administration of epinephrine ― 54%, minimal use of epinephrine is observed among children under 3 years of age.
作者简介
Alexander Pampura
Morozov Children's Municipal Clinical Hospital; Veltischev Research and Clinical Institute for Pediatrics and Pediatric Surgery of the Pirogov Russian National Research Medical University of the Russian Ministry of Health
Email: apampura@pedklin.ru
ORCID iD: 0000-0001-5039-8473
SPIN 代码: 9722-7961
MD, Dr. Sci. (Med.), Professor
俄罗斯联邦, Moscow; MoscowNatalia Esakova
Veltischev Research and Clinical Institute for Pediatrics and Pediatric Surgery of the Pirogov Russian National Research Medical University of the Russian Ministry of Health
编辑信件的主要联系方式.
Email: env007@rambler.ru
ORCID iD: 0000-0001-8792-2670
SPIN 代码: 6924-9726
MD, Cand. Sci. (Med.)
俄罗斯联邦, MoscowSergey Zimin
Morozov Children's Municipal Clinical Hospital
Email: 23otd@morozdgkb.ru
ORCID iD: 0000-0002-4514-8469
SPIN 代码: 4363-1578
MD
俄罗斯联邦, MoscowEkaterina Кovtun
Morozov Children's Municipal Clinical Hospital
Email: EKovtun@morozdgkb.ru
ORCID iD: 0000-0002-1508-314X
SPIN 代码: 6219-0640
MD
俄罗斯联邦, MoscowYanina Kara
Morozov Children's Municipal Clinical Hospital
Email: Yolegovna@morozdgkb.ru
ORCID iD: 0009-0009-6929-141X
SPIN 代码: 7472-9934
MD
俄罗斯联邦, MoscowElena Busova
Morozov Children's Municipal Clinical Hospital
Email: ESBusova@morozdgkb.ru
ORCID iD: 0009-0009-9121-5501
MD
俄罗斯联邦, MoscowZareta Bzhekshieva
Morozov Children's Municipal Clinical Hospital
Email: ZBzhekshieva@morozdgkb.ru
ORCID iD: 0009-0009-7375-7526
SPIN 代码: 9844-6674
MD
俄罗斯联邦, MoscowMarina Leonteva
Morozov Children's Municipal Clinical Hospital
Email: MLeonteva@morozdgkb.ru
ORCID iD: 0000-0002-0799-1025
SPIN 代码: 1128-8656
MD
俄罗斯联邦, MoscowIrina Vitkovskaya
Morozov Children's Municipal Clinical Hospital
Email: IVitkovskaya@morozdgkb.ru
ORCID iD: 0000-0002-0740-1558
SPIN 代码: 2970-0361
MD, Cand. Sci. (Med.)
俄罗斯联邦, MoscowValery Gorev
Morozov Children's Municipal Clinical Hospital
Email: mdgkb@zdrav.mos.ru
ORCID iD: 0000-0001-8272-3648
SPIN 代码: 8944-9664
MD, Cand. Sci. (Med.)
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