Tacrolimus in moderate and severeatopic dermatitis treatment. The first clinical experience in Russia
- 作者: Elisyutina O.1, Fedenko E1, Shtyrbul O1, Niyazov D1, Elisyutina O2, Fedenko E2, Shtyrbul O2, Niyazov D2
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隶属关系:
- ФГБУ «ГНЦ Институт иммунологии» ФМБА России
- Institute of Immunology
- 期: 卷 8, 编号 6 (2011)
- 页面: 68-76
- 栏目: Articles
- URL: https://journals.rcsi.science/raj/article/view/121356
- DOI: https://doi.org/10.36691/RJA822
- ID: 121356
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详细
Methods. There were 19 moderate and 11 severe AD patients under supervision. Treatment with tacrolimus ointment 0,1% was started with twice a day application. Duration of this treatment was from 1 to 4 weeks (18±4,2 days) up to skin clearance. When symptoms were reduced, the frequency of tacrolimus application was reduced as well to once a day daily, and than to twice a week. Generally, improvement was observed within one week of treatment. Clinical efficiency was assessed by SCORAD index and Investigators' Global Assessment (IGA). Results. Positive clinical effect of tacrolimus 0,1% ointment therapy was found in 90% of AD patients resulted in significant reduction of dryness, rushes, skin itch, SCORAD and IGA indexes.
Conclusion. Tacrolimus 0,1% ointment is effective and safe for treatment of severe and moderate AD. It should be applied both as exacerbations treatment and as maintenance therapy in AD patients.
作者简介
Ol'ga Elisyutina
ФГБУ «ГНЦ Институт иммунологии» ФМБА России
Email: el-olga@yandex.ru
ФГБУ «ГНЦ Институт иммунологии» ФМБА России
E Fedenko
ФГБУ «ГНЦ Институт иммунологии» ФМБА РоссииФГБУ «ГНЦ Институт иммунологии» ФМБА России
O Shtyrbul
ФГБУ «ГНЦ Институт иммунологии» ФМБА РоссииФГБУ «ГНЦ Институт иммунологии» ФМБА России
D Niyazov
ФГБУ «ГНЦ Институт иммунологии» ФМБА РоссииФГБУ «ГНЦ Институт иммунологии» ФМБА России
O Elisyutina
Institute of ImmunologyInstitute of Immunology
E Fedenko
Institute of ImmunologyInstitute of Immunology
O Shtyrbul
Institute of ImmunologyInstitute of Immunology
D Niyazov
Institute of ImmunologyInstitute of Immunology
参考
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