Forensic medical assessment of morphological changes in the myocardium, affecting its contractile capacity in cases of death from alcoholic cardiomyopathy

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A retrospective analysis of acts of forensic medical autopsies from the archive of BSME and a histological study of myocardial tissue in 180 cases (87 women and 93 men) were carried out with statistical processing of the obtained results for the purpose of studying and assessing the morphological changes in the main components of the histohematological barrier of myocardium, affecting the contractility of the cardiac muscle in cases of the death from alcoholic cardiomyopathy. As a result of the study, it was found that the occurrence of metabolic disturbances due to the toxic effects of ethanol and its metabolites contribute to the development of hypoxia of the heart muscle with the development of dystrophic and irreversible necrobiotic processes in it, which in its turn play a direct role in the formation of excitability processes, contractile function of myofibrils with the development of fatal rhythm disorders. The morphological changes in the contractile apparatus of the myocardium were discovered in the study in polarized light and can be used to diagnose alcohol damage to the heart. During the study of deaths from alcoholic cardiomyopathy in forensic medicine, it is recommended to use methods of polarization microscopy.

作者简介

Olga Sokolova

St. Petersburg State Pediatric Medical University

编辑信件的主要联系方式.
Email: last_hope@inbox.ru

MD, PhD, Associate Professor, Department of Pathological Anatomy with the Course of Forensic Medicine

俄罗斯联邦, Saint Petersburg

Orazmurad Yagmurov

Academician I.P. Pavlov First St. Petersburg State Medical University 

Email: oraz.yagmurov@gmail.com

MD, PhD, Dr Med Sci, Professor, Head, Department of Forensic Medicine and Jurisprudence

俄罗斯联邦, Saint Petersburg

Ruslan Nasyrov

St. Petersburg State Pediatric Medical University

Email: ran53@mail.ru

MD, PhD, Dr Med Sci, Professor, Head, Department of Pathological Anatomy with the Course of Forensic Medicine

俄罗斯联邦, Saint Petersburg, Russia

参考

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版权所有 © Sokolova O.V., Yagmurov O.D., Nasyrov R.A., 2018

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