Primary hyperparathyroidism in childhood
- 作者: Gostimsky A.1, Matveeva Z.1, Romanchishen A.1, Karpatskiy I.1, Peredereev S.1, Lisovskiy O.1, Pogorelchuk V.1
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隶属关系:
- St. Petersburg State Pediatric Medical University
- 期: 卷 8, 编号 5 (2017)
- 页面: 20-24
- 栏目: Articles
- URL: https://journals.rcsi.science/pediatr/article/view/7530
- DOI: https://doi.org/10.17816/PED8520-24
- ID: 7530
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详细
Primary hyperparathyroidism is a disease caused by excessive production of parathyroid hormone by the parathyroid glands. Most often, sporadic cases of the disease occur. In the family form of hyperparathyroidism, as well as in the syndrome of multiple endocrine neoplasia, the disease is caused by genetic changes. In manifest forms of the disease, hyperparathyroidism leads to destruction and deformation of bone tissue, osteoporosis, urolithiasis, cholelithiasis, pancreatitis, peptic ulcer disease, and disorders of mineral and electrolyte metabolism. Bone manifestations of the disease can lead to disability of the child. The article presents the experience of surgical treatment of 15 children, patients with primary hyperparathyroidism, aged from 6 to 18 years old, 10 of them girls and 5 boys operated in the period from 1973 to 2017. The main methods of diagnosis of the disease, the difficulties of timely diagnostic are discussed. The features of laboratory indicators of clinical manifestations of the disease are clearly shown. The clinical manifestations of primary hyperparathyroidism in children differed from adults more heavily damage of bone tissue with the development of gross deformities of the limbs. In 8 (57.3%) of 15 children, manifest forms of the disease were diagnosed. In 7 (46.7%) children, parathyroid adenomas were detected and removed during surgery for various thyroid diseases. In two patients, parathyroid adenomas were removed during operations performed for a genetically confirmed syndrome of multiple endocrine neoplasia of type IIa. In this study, the features of adenoma localization of the parathyroid gland, the possibility of surgical treatment and the dynamics of clinical manifestations after surgery are discussed. Proper treatment allowed to achieve full recovery.
作者简介
Alexandr Gostimsky
St. Petersburg State Pediatric Medical University
编辑信件的主要联系方式.
Email: gostimsky@mail.ru
MD, PhD, Dr Med Sci, Professor, Head, Department of General Medical Practice
俄罗斯联邦, St. PetersburgZoya Matveeva
St. Petersburg State Pediatric Medical University
Email: ikar122@list.ru
MD, PhD, Assistant Professor, Department of Hospital Surgery with Traumatology and Military Surgery Courses
俄罗斯联邦, St. PetersburgAnatoliy Romanchishen
St. Petersburg State Pediatric Medical University
Email: afromanchishen@mail.ru
MD, PhD, Dr Med Sci, Professor, Head, Department of Hospital Surgery with Traumatology and Military Surgery Courses
俄罗斯联邦, St. PetersburgIgor Karpatskiy
St. Petersburg State Pediatric Medical University
Email: ivspb@mail333.com
MD, PhD, Associate Professor, Department of General and Medical Chemistry
俄罗斯联邦, St. PetersburgSergey Peredereev
St. Petersburg State Pediatric Medical University
Email: speredereev@yandex.ru
Resident doctor, Surgical Department No 3
俄罗斯联邦, St. PetersburgOleg Lisovskiy
St. Petersburg State Pediatric Medical University
Email: oleg.lisovsky@rambler.ru
MD, PhD, Associate Professor, Department of General and Medical Chemistry
St. PetersburgVictor Pogorelchuk
St. Petersburg State Pediatric Medical University
Email: viktor-pogorelchuk@yandex.ru
MD, PhD, Associate Professor, Department of General and Medical Chemistry
俄罗斯联邦, St. Petersburg参考
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