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Post a Comment Comparative assesment of efficiency application cold atmospheric plasma and biopolymerous coats evaluation of the effectiveness for the treatment of skin burns of iii degree in experiment
- Authors: Zinovyev E.V.1, Asadulaev M.S.1, Komissarov I.A.1, Shemet M.V.2, Yudin V.E.2, Shabunin A.S.2, Smirnova N.V.2, Kryukov A.E.2, Lukyanov S.A.1, Stoyanovskiy R.G.1, Shalonia T.A.1, Artsimovich I.V.1, Kostyakov D.V.1
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Affiliations:
- St Petersburg State Pediatric Medical University
- Peter the Great St Petersburg Polytechnic University
- Issue: Vol 8, No 3 (2017)
- Pages: 23-31
- Section: Articles
- URL: https://journals.rcsi.science/pediatr/article/view/6693
- DOI: https://doi.org/10.17816/PED8323-31
- ID: 6693
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Abstract
The results of the application of cold atmospheric plasma are discussed in the experimental study. The effectiveness of an experimental wound dressing based on chitosan nanofibers and copolyamide and a commercial wound dressing material based on hyaluronic acid hydrogel in the treatment of third-degree skin burns (ICD-10) is also evaluated. During the first phase of the study, an original method of inflicting thermal burn on the skin of small laboratory animals (rodents) was developed. The temperature of dehaired skin and the temperature of skin heated by resistive electrical element metal plate were obtained through a digital thermometer sensor. The source for the generation of cold atmospheric plasma was made by specialists of St. Petersburg Polytechnic University of Peter the Great. Biopsy material for histological assay was taken 3, 7, 12, 15, 21, and 28 days after treatment. Paraffinic microscopic sectioning was performed with hematoxylin and eosin; after this, microscopic assay was done. The use of cold atmospheric plasma decreases the frequency of purulent complications and also helps reduce the recovery time of the skin by 20% (p < 0.05) but is not sufficient to achieve the result that has been proclaimed after an early escharectomy and replacement of surgical defects by wound dressing materials based on natural polymers. It was demonstrated that the wound dressing based on aliphatic copolyamide and chitosan and hyaluronic acid hydrogel can help significantly accelerate the process of reparative regeneration and histogenesis in the heat-affected zone after escharectomy for up to 14.6%-46% (p < 0.05).
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##article.viewOnOriginalSite##About the authors
Evgeny V. Zinovyev
St Petersburg State Pediatric Medical University
Author for correspondence.
Email: evz@list.ru
MD, PhD, Dr Med Sci Professor, Department of Hospital Surgery with Traumatology and Military Surgery Courses
Russian Federation, Saint PetersburgMarat S. Asadulaev
St Petersburg State Pediatric Medical University
Email: marat.asadulaev@yandex.ru
Department of Surgical Diseases of Childhood
Russian Federation, Saint PetersburgIgor A. Komissarov
St Petersburg State Pediatric Medical University
Email: komissarov_i_a@mail.ru
MD, PhD, Dr Med Sci Professor, Head, Department of Surgical Diseases of Childhood
Russian Federation, Saint PetersburgMihail V. Shemet
Peter the Great St Petersburg Polytechnic University
Email: mvshemet@gmail.com
PhD, Associate Professor. Department of High Voltage Engineering, Electrical Insulation and Cable Technology
Russian Federation, Saint PetersburgVladimir E. Yudin
Peter the Great St Petersburg Polytechnic University
Email: yudinve@gmail.com
Dr Sci Professor, Head. Institute of Physics, Nanotechnology and Telecommunications, Department of Medical Physics, Laboratory of Polymeric Materials for Tissue Engineering and Transplantology
Russian Federation, Saint PetersburgAnton S. Shabunin
Peter the Great St Petersburg Polytechnic University
Email: anton-shab@yandex.ru
Institute of Physics, Nanotechnology and Telecommunications, Department of Medical Physics, Laboratory of Polymeric Materials for Tissue Engineering and Transplantology
Russian Federation, Saint PetersburgNatalia V. Smirnova
Peter the Great St Petersburg Polytechnic University
Email: nvsmirnoff@yandex.ru
PhD Researcher. Institute of Physics, Nanotechnology and Telecommunications, Department of Medical Physics, Laboratory of Polymeric Materials for Tissue Engineering and Transplantology
Russian Federation, Saint PetersburgArtem E. Kryukov
Peter the Great St Petersburg Polytechnic University
Email: kryukov14@gmail.com
Institute of Physics, Nanotechnology and Telecommunications, Department of Medical Physics, Laboratory of Polymeric Materials for Tissue Engineering and Transplantology
Russian Federation, Saint PetersburgSergey A. Lukyanov
St Petersburg State Pediatric Medical University
Email: stalker125lu@yandex.ru
Department of Surgical Diseases of Childhood
Russian Federation, Saint PetersburgRoman G. Stoyanovskiy
St Petersburg State Pediatric Medical University
Email: explabgpmu@gmail.com
Assistant Professor, Department of Human Anatomy
Russian Federation, Saint PetersburgTatiana A. Shalonia
St Petersburg State Pediatric Medical University
Email: tanyaiudina@mail.ru
MD, PhD, Assistant Professor, Department of Pathological Anatomy at the Rate of Forensic Medicine
Russian Federation, Saint PetersburgIlya V. Artsimovich
St Petersburg State Pediatric Medical University
Email: enerdgezer@yandex.ru
Department of Surgical Diseases of Childhood
Russian Federation, Saint PetersburgDenis V. Kostyakov
St Petersburg State Pediatric Medical University
Email: kostyakovdv@gmail.com
Department of Pathologic Physiology Courses Immunopathology and Medical Informatics
Russian Federation, Saint PetersburgReferences
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