Cytokines as markers of non-functional overstrain in rowing athletes
- Authors: Mamiev N.D.1, Vasilenko V.S.1, Semenova Y.B.1, Karpovskaya E.B.1, Merkulova A.V.1, Kanavets N.S.1, Ivanov V.S.1
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Affiliations:
- Saint Petersburg State Pediatric Medical University
- Issue: Vol 15, No 1 (2024)
- Pages: 55-64
- Section: Original studies
- URL: https://journals.rcsi.science/pediatr/article/view/263096
- DOI: https://doi.org/10.17816/PED15155-63
- ID: 263096
Cite item
Abstract
BACKGROUND: Regular high-intensity exercise, combined with other stressors and lack of adequate recovery time, can cause a sustained pro-inflammatory response, leading to systemic inflammation and immune dysregulation.
AIM: The aim of this study is to establish the prognostic effectiveness of proinflammatory IL-1β, TNFα, IL-8, anti-inflammatory cytokine IL-4 and myokine IL-6 as markers of dysfunctional overstrain and overtraining in rowing athletes.
MATERIALS AND METHODS: A total of 47 male athletes aged 18–22 years were examined, specializing in rowing, 1st category, candidates for master of sports. Of these, 28 were dynamic (4 times). The control group included 24 healthy donors, men aged 18–22 years. Cardiac overstrain was diagnosed based on 24-hour ECG data: identification of ventricular and supraventricular extrasystoles in the absence of organic changes in the heart. The content of cytokines in blood serum was determined using the Human Cytokine/Chemokine Magnetic Bead Panel 1 reagents (Merck, Millipore) on a MagPix device. The research results were processed using parametric statistics methods.
RESULTS: Rowing athletes show an increase in pro-inflammatory cytokines, which can be both a consequence of adaptive changes and a sign of long-term systemic inflammation. Determination of IL-6, IL-8, TNFα may be useful for assessing the body’s adaptation to training loads. The greatest changes in the level of pro-inflammatory cytokines are observed during the competitive period, and it should be taken into account that an increase in the anti-inflammatory cytokine IL-4 occurs in response to high levels of pro-inflammatory cytokines and is a sign of good adaptation.
CONCLUSIONS: The greatest importance in the diagnosis of non-functional cardiac overstrain in rowing athletes should be given to an increase in IL-1α and IL-6 and an increase in TNFα against the background of a decrease in IL-4.
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##article.viewOnOriginalSite##About the authors
Nazar D. Mamiev
Saint Petersburg State Pediatric Medical University
Email: nazarmamiev1986@yandex.ru
ORCID iD: 0000-0002-1292-306X
SPIN-code: 9834-5762
Assistant Professor, Department of Hospital Therapy with Endocrinology Course
Russian Federation, 2 Litovskaya st., Saint Petersburg, 194100Vladimir S. Vasilenko
Saint Petersburg State Pediatric Medical University
Email: vasilenkovladi@yandex.ru
ORCID iD: 0000-0002-8833-304X
SPIN-code: 1355-1790
MD, PhD, Dr. Sci. (Medicine), Head, Department of Hospital Therapy with Endocrinology Course
Russian Federation, 2 Litovskaya st., Saint Petersburg, 194100Yuliya B. Semenova
Saint Petersburg State Pediatric Medical University
Email: ulasema@rambler.ru
ORCID iD: 0000-0002-4397-7079
SPIN-code: 9868-7645
MD, PhD, Associate Professor, Department of Hospital Therapy with Endocrinology Course
Russian Federation, 2 Litovskaya st., Saint Petersburg, 194100Ekaterina B. Karpovskaya
Saint Petersburg State Pediatric Medical University
Email: karpovskaya@yandex.ru
ORCID iD: 0000-0003-2363-6100
SPIN-code: 5214-2693
MD, PhD, Associate Professor, Department of Hospital Therapy with Endocrinology Course
Russian Federation, 2 Litovskaya st., Saint Petersburg, 194100Anna V. Merkulova
Saint Petersburg State Pediatric Medical University
Email: dr_anmerkulova@mail.ru
ORCID iD: 0009-0006-3732-6890
Assistant Professor, Department of Hospital Therapy with Endocrinology Course
Russian Federation, 2 Litovskaya st., Saint Petersburg, 194100Natalia S. Kanavets
Saint Petersburg State Pediatric Medical University
Email: natalia.kanavets@mail.ru
ORCID iD: 0000-0003-4693-4338
SPIN-code: 1652-8330
MD, PhD, Assistant Professor, Department of Hospital Therapy with Endocrinology Course
Russian Federation, 2 Litovskaya st., Saint Petersburg, 194100Vladimir S. Ivanov
Saint Petersburg State Pediatric Medical University
Author for correspondence.
Email: ulasema@rambler.ru
ORCID iD: 0000-0001-5705-7057
SPIN-code: 5790-9543
MD, PhD, Associate Professor, Department of Hospital Therapy with Endocrinology Course
Russian Federation, 2 Litovskaya st., Saint Petersburg, 194100References
- Badtieva VA, Pavlov VI, Sharykin AS, et al. An overtraining syndrome as functional cardiovascular disorder due to physical overload. Russian Journal of Cardiology. 2018;23(6):180–190. EDN: XSLTVZ doi: 10.15829/1560-4071-2018-6-180-190
- Vasilenko VS, Levin MYa, Semyonova YuB, Nazarov PG. Cytokines as markers of the cardiovascular overexertion in athletes. Cytokines and Inflammation. 2015;14(1):86–90. EDN: UZMOPX
- Danilenko L, Kalinina M, Kalinin A, et al. Recovery treatment overstrain syndrome of back muscles in rowing and swimming athletes. Medicine: Theory and Practice. 2023;8(2):10–16. EDN: KJEPAH doi: 10.56871/MTP.2023.11.17.002
- Zemtsovsky EV. Sport cardiology. Saint Petersburg: Hippocrates; 1995. 448 p. (In Russ.) EDN: VJXJVB
- Lopatin ZV, Vasilenko VS, Karpovskaya EB. Role of endothelium damage factors in the pathogenesis of cardiomyopathy surge in athletes sports. Pediatrician (St. Petersburg). 2018;9(6):57–62. EDN: FBOJYS doi: 10.17816/PED9657-62
- Lysenko LM, Kuznetsova OA, Shilina LV. Pathologic changes in the cardiovascular system in athletes against the background of physical overstrain syndrome. Russian Medical Journal. 2015;23(4):239. (In Russ.)
- Sushentseva NN, Popov OS, Apalko SV, et al. Biobank as a source of samples for determination of concentration reference ranges for cytokines, chemokines and growth factors circulating in the blood. Cardiovascular Therapy and Prevention. 2022;21(11):25–32. EDN: NEVOCC doi: 10.15829/1728-8800-2022-3396
- Armstrong LE, Bergeron MF, Lee EC, et al. Overtraining syndrome as a complex systems phenomenon. Front Netw Physiol. 2022;1:794392. doi: 10.3389/fnetp.2021.794392
- Beiter T, Hoene M, Prenzler F, et al. Exercise, skeletal muscle and inflammation: ARE-binding proteins as key regulators in inflammatory and adaptive networks. Exerc Immunol Rev. 2015;21: 42–57.
- Bernardo BC, Weeks KL, Pretorius L, McMullen JR. Molecular distinction between physiological and pathological cardiac hypertrophy: Experimental findings and therapeutic strategies. Pharmacol Ther. 2010;128(1):191–227. doi: 10.1016/j.pharmthera.2010.04.005
- Carrard J, Rigort AC, Appenzeller-Herzog C, et al. Diagnosing overtraining syndrome: A scoping review. Sports Health. 2022;14(5):665–673. doi: 10.1177/19417381211044739
- Cerqueira E, Marinho DA, Neiva HP, Lourenco O. Inflammatory effects of high and moderate intensity exercise — a systematic review. Front Physiol. 2019;10:1550. doi: 10.3389/fphys.2019.01550.
- Craighead DH, Heinbockel TC, Freeberg KA, et al. Time-efficient inspiratory muscle strength training lowers blood pressure and improves endothelial function, no bioavailability, and oxidative stress in midlife/older adults with above-normal blood pressure. J Am Heart Assoc. 2021;10(13): e020980. doi: 10.1161/JAHA.121.020980
- da Rocha AL, Pinto AP, Kohama EB, et al. The proinflammatory effects of chronic excessive exercise. Cytokine. 2019;119:57–61. doi: 10.1016/j.cyto.2019.02.016
- Kurowski M, Seys S, Bonini M, et al. Physical exercise, immune response, and susceptibility to infections — current knowledge and growing research areas. Allergy. 2022;77(9):2653–2664. doi: 10.1111/all.15328
- La Gerche A, Inder WJ, Roberts TJ, et al. Relationship between inflammatory cytokines and indices of cardiac dysfunction following intense endurance exercise. PloS one. 2015;10(6):e0130031. doi: 10.1371/journal.pone.0130031
- Lee ЕС, Fragala MS, Kavouras SA, et al. Biomarkers in sports and exercise. J Strength Cond Res. 2017;31(10):2920–2937. doi: 10.1519/JSC.0000000000002122
- Luoto R, Ruuskanen O, Ihalainen JK, et al. Inflammatory biomarkers in elite cross-country skiers after a competition season: a case-control study. Journal of Science in Sport and Exercise. 2023;5(3):254–262. doi: 10.1007/s42978-022-00186-w
- Małkowska P, Sawczuk M. Cytokines as biomarkers for evaluating physical exercise in trained and non-trained individuals: a narrative review. Int J Mol Sci. 2023;24(13):11156. doi: 10.3390/ijms241311156
- Palmowski J, Kohnhorst S, Bauer P, et al. T-cell-derived TNF-α and a cluster of immunological parameters from plasma allow a separation between SARS-CoV-2 convalescent versus vaccinated elite athletes. Front Physiol. 2023;14:1203983. doi: 10.3389/fphys.2023.1203983
- Roth J, Szczygiel T, Moore M, et al. Profiling inflammatory markers during the competitive season and post season in collegiate wrestlers. J Strength Cond Res. 2019;33(8):2153–2161. doi: 10.1519/JSC.0000000000002360
- Selye HA. Syndrome produced by diverse nocuous agents. Nature. 1936;138(3479):32. doi: 10.1038/138032a0
- Symons IK, Bruce L, Main LC. Impact of overtraining on cognitive function in endurance athletes: a systematic review. Sports Medicine-Open. 2023;9(1):69. doi: 10.1186/s40798-023-00614-3
- Tesema G, George M, Mondal S, Mathivana D. Serum cardiac markers are inversely associated with VO2max of amateur athletes in response to endurance training adaptations. BMJ Open Sport Exerc Med. 2019;5(1): e000537. doi: 10.1136/bmjsem-2019-000537
- Van Den Eeckhout B, Tavernier J. Interleukin-1 as innate mediator of T cell immunity. Front Immunol. 2021;11:621931. doi: 10.3389/fimmu.2020.621931
- Xu X. Effects of regular exercise on inflammasome activation-related inflammatory cytokine levels in older adults: a systematic review and meta-analysis. J Sports Sci. 2021;39(20)2338–2352. doi: 10.1080/02640414.2021.1932279