Clinical ambiguousness of measurement of tumor markers in the differential diagnosis of the uterus appendages tumors and inflam-matory pelvic mass in girls
- Authors: Kokhreidze N.A.1, Leontyeva S.A.1
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Affiliations:
- Saint Petersburg State Pediatric Medical University
- Issue: Vol 6, No 1 (2015)
- Pages: 115-119
- Section: Articles
- URL: https://journals.rcsi.science/pediatr/article/view/1047
- DOI: https://doi.org/10.17816/PED61115-119
- ID: 1047
Cite item
Abstract
In the diagnosis of ovarian tumors, with the most frequent gystotypes specific to childhood and adolescence, is widely used of tumor markers tests: alpha-fetoprotein (AFP), human chorionic gonadotropin (hCG) and Ca-125. Features of the development of malignancies in children restrict of tumor markers tests in clinical practice. At the same time there are no tumor marker with 100 % specificity for the tumor. The article describes the clinical cases of 13-year-old female patient with appendicular infiltrate and secondary right adnekstumor and 14-year-old girl with hematogenous disseminated tuberculosis and salpingooophorities. The levels of Ca-125 and was an increased in both cases: in the first - to 39.41 IU/ml, in the second - up to 928.1 IU/ml. Thus, it was confirmed that the increase of serum concentration of CA-125 were in direct proportion to the pathological “irritation” of peritoneal serosa. In fact, the Ca-125 had the feature of acute phase proteins, so, its tumor specificity was low. Therefore the use of tumor marker test for Ca-125 is not always makes more easy task of differential diagnosis of the nature of the tumor mass pelvic in girls.
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##article.viewOnOriginalSite##About the authors
Nadezda Anatolyevna Kokhreidze
Saint Petersburg State Pediatric Medical University
Email: kokhreidze@mail.ru
MD, PhD, Associate Professor. Department of Children Gynecology and Female Reproductology, Faculty of Postgraduate Education
Svetlana Alekseevna Leontyeva
Saint Petersburg State Pediatric Medical University
Email: Sonik1977@yandex.ru
Postgraduate Student, Department of Obstetrics & Gynecology
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