动物动脉粥样硬化的发展中脂质代谢和全身炎症的作用的比较评估

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全身性炎症对动脉粥样硬化的发病机理有重要贡献，并且是众多研究的主题。旨在分析动脉粥样硬化发展机制的作品，通常包括动物实验。描述、论证和选择适当的模型是每项此类研究的首要任务。

目的：慢性阻塞性肺疾病（COPD）动脉粥样硬化动物模型脂质代谢和全身炎症特征的评价。

材料和方法。对小鼠、大鼠和家兔的脂质代谢和免疫应答的物种特异性特征进行了交叉连接分析，并对Toll样受体4（TLR4）与人类的差异进行了生物信息学分析。在国家生物技术信息中心（NCBI）和通用蛋白质资源（UniProt）的GenBank国际数据库中，对人、小鼠、大鼠和兔TLR4受体的氨基酸序列进行了搜索和分析。多受体氨基酸序列比对在Clustal Omega软件1.2.4版中执行。分子系统发育树的重建与可视化使用MEGA7程序根据最近邻居的方法（英语：Neighbor-Joining）和最大经济性的方法（英语：Maximum Parsimony）。

结果。研究结果表明，人类、小鼠和家兔在脂代谢特征上存在种属特异性差异，在分析研究结果时应予以考虑。

结论。由固有免疫系统介导的脂质代谢异常和全身性炎症与COPD的动脉粥样硬化的发病机制有关，在分析研究结果时必须考虑到特定物种的特征。

作者简介

Stanislav Kotlyarov

Ryazan State Medical University

编辑信件的主要联系方式.
Email: SKMR1@yandex.ru
ORCID iD: 0000-0002-7083-2692
SPIN 代码: 3341-9391
Researcher ID: Q-3633-2017

MD, PhD, Head of the Nurse Department

俄罗斯联邦, Ryazan, Russia

Anna Kotlyarova

Ryazan State Medical University

Email: kaa.rz@yandex.ru
SPIN 代码: 9353-0139
Researcher ID: K-7882-2018

PhD in Biological Sciences, Assistant of the Department of Pharmacology with the Course of Pharmacy of the Faculty of Additional Professional Education

俄罗斯联邦, Ryazan, Russia

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