电邮这篇文章 肿瘤患者凝凝血因子基因多态性变体流行的研究
- 作者: Zykova T.1, Vladimirova L.1, Katelnitskaya O.1, Maslov A.1, Shevyakova E.1, Lysenko I.1, Abramova N.1, Storozhakova A.1, Popova I.1, Novoselova K.1, Tikhanovskaya N.1, Lyanova A.1, Ryadinskaya L.1, Tishina A.1, Tishchenko I.1, Kabanov S.1, Kalabanova E.1
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隶属关系:
- Rostov Research Institute of Oncology
- 期: 卷 28, 编号 1 (2020)
- 页面: 44-56
- 栏目: Original study
- URL: https://journals.rcsi.science/pavlovj/article/view/16376
- DOI: https://doi.org/10.23888/PAVLOVJ202028144-56
- ID: 16376
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详细
目的：研究肿瘤患者凝凝血因子基因多态性等位基因变异携带者的频率。
材料与方法：对213例经形态学证实的肿瘤疾病患者进行了检查。从患者的外周血基因组DNA样本进行了检查。采用聚合酶链反应 (PCR) 实时研究止血系统基因多态位点：F2 (G20210А, rs1799963)、F5 (G1691A, rs6025) 、F7 (G10976A, rs6046)、F13 (G226A, rs5985) 、FGB G (-455) A (rs1800790) , ITGA2-α2 (C807T, rs1126643) 、ITGB3-b (Т1565С, rs5918) 、PAI-1 4G (-675) 5G 、rs1799889) 。
结果：研究组F2 (G20210A) 多态位点的选择等位基因的载频为1.6%，F5 (G1691A) – 3,5%, F7 (G10976A) – 13,4%, F13 (G226A) – 28,2%, FGB G (-455) A – 24,9%, ITGA2-α2 (C807T) – 41,5%, ITGB3-b (Т1565С) – 15,5%, PAI-1 4G (-675) 5G – 56,6%。与普通人群相比，我们发现了，癌症患者中F5 G1691A (р=0,0169) , F13 G226A (р=0,0007) , FGB G (-455) A (р<0,0001) 及ITGA2-α2 C807T (р=0,0201) 多态位点的《风险等位基因》的患病率明显高于普通人群。在同一基因座，除了ITGA2-α2 (C807T) ，在癌症过程的各种局部化中发现替代等位基因流行频率的统计学显着差异。在92.0%的患者中，在止血系统的不同部位检测到了SNP的组合。
结论：考虑到凝血系统各部分《风险等位基因》检测频率较高，建议对癌症患者进行额外的研究工作，以确定是否需要在抗血栓治疗中添加抗血小板药物。
作者简介
Tatiana Zykova
Rostov Research Institute of Oncology
编辑信件的主要联系方式.
Email: tatiana2904@yandex.ru
ORCID iD: 0000-0001-5345-4872
SPIN 代码: 7054-0803
Scopus 作者 ID: 57200075494
Researcher ID: U-3559-2019
MD, PhD, Head of the Laboratory of Virology
俄罗斯联邦, Rostov- on-DonLyubov Vladimirova
Rostov Research Institute of Oncology
Email: rnioi@list.ru
ORCID iD: 0000-0003-4236-6476
SPIN 代码: 4857-6202
Researcher ID: U-8132-2019
MD, PhD, Professor, Head of the Department of Anticancer Drug Therapy №1
俄罗斯联邦, Rostov-on-DonOksana Katelnitskaya
Rostov Research Institute of Oncology
Email: Katelnitskayaov@rnioi.ru
MD, PhD, Cardiovascular Surgeon of the Department of Abdominal Oncology № 2
俄罗斯联邦, Rostov-on-DonAndrey Maslov
Rostov Research Institute of Oncology
Email: Maslovaa@rnioi.ru
ORCID iD: 0000-0003-4902-5789
SPIN 代码: 5963-5915
Researcher ID: W-5180-2019
MD, PhD, Professor, Honored Doctor of the Russian Federation, Chief Physician, Head of the Department of Abdominal Oncology №3
俄罗斯联邦, Rostov-on-DonElena Shevyakova
Rostov Research Institute of Oncology
Email: Shevyakovaea@rnioi.ru
ORCID iD: 0000-0002-4232-6733
SPIN 代码: 9595-7616
Researcher ID: U-3551-2019
Biologist of Laboratory Virology
俄罗斯联邦, Rostov-on-DonIrina Lysenko
Rostov Research Institute of Oncology
Email: Lysenkoib@rnioi.ru
ORCID iD: 0000-0003-4457-3815
SPIN 代码: 9510-3504
MD, PhD, Head of the Department of Oncohematology
俄罗斯联邦, Rostov-on-DonNatalia Abramova
Rostov Research Institute of Oncology
Email: Abramovana@rnioi.ru
ORCID iD: 0000-0001-7793-9794
SPIN 代码: 1784-8819
Researcher ID: U-6181-2019
MD, PhD, Oncologist of Department of Anticancer Drug Therapy №1
俄罗斯联邦, Rostov-on-DonAnna Storozhakova
Rostov Research Institute of Oncology
Email: Storozhakovaae@rnioi.ru
MD, PhD, Head of the Department of Anticancer Drug Therapy №2
俄罗斯联邦, Rostov-on-DonIrina Popova
Rostov Research Institute of Oncology
Email: Popovail@rnioi.ru
ORCID iD: 0000-0003-4865-8832
SPIN 代码: 4542-1937
Researcher ID: U-6397-2019
MD, PhD, Oncologist of the Department of Anticancer Drug Therapy №1
俄罗斯联邦, Rostov-on-DonKristina Novoselova
Rostov Research Institute of Oncology
Email: Novoselovaka@rnioi.ru
ORCID iD: 0000-0002-7059-9026
SPIN 代码: 3492-1620
Researcher ID: V-1130-2017
MD, PhD, Oncologist of the Department of Anticancer Drug Therapy №1
俄罗斯联邦, Rostov-on-DonNatalya Tikhanovskaya
Rostov Research Institute of Oncology
Email: Tikhanovskayanm@rnioi.ru
ORCID iD: 0000-0001-5139-2639
SPIN 代码: 9000-4877
Researcher ID: U-8128-2019
Oncologist of the Department of Anticancer Drug Therapy №1
俄罗斯联邦, Rostov-on-DonAza Lyanova
Rostov Research Institute of Oncology
Email: Lyanovaaa@rnioi.ru
Oncologist of the Department of Anticancer Drug Therapy №1
俄罗斯联邦, Rostov-on-DonLyudmila Ryadinskaya
Rostov Research Institute of Oncology
Email: Ryadinskayala@rnioi.ru
ORCID iD: 0000-0002-5964-2513
SPIN 代码: 6146-2396
Researcher ID: U-6199-2019
MD, PhD, Oncologist of the Department of Anticancer Drug Therapy №1
俄罗斯联邦, Rostov-on-DonAnna Tishina
Rostov Research Institute of Oncology
Email: Tishinaav@rnioi.ru
ORCID iD: 0000-0002-7990-8710
SPIN 代码: 7686-3707
Researcher ID: H-2460-2018
Oncologist of the Department of Anticancer Drug Therapy №2
俄罗斯联邦, Rostov-on-DonIrina Tishchenko
Rostov Research Institute of Oncology
Email: Tishchenkois@rnioi.ru
ORCID iD: 0000-0002-4990-0881
SPIN 代码: 7705-2954
Researcher ID: W-5183-2019
Surgeon of the Department of Thoracic Surgery
俄罗斯联邦, Rostov-on-DonSergey Kabanov
Rostov Research Institute of Oncology
Email: Kabanovsn@rnioi.ru
MD, PhD, Oncologist of the Department of Anticancer Drug Therapy №2
俄罗斯联邦, Rostov-on-DonElena Kalabanova
Rostov Research Institute of Oncology
Email: Kalabanovaea@rnioi.ru
ORCID iD: 0000-0003-0158-3757
SPIN 代码: 9090-3007
Researcher ID: V-2943-2019
MD, PhD, Oncologist of the Department of Anticancer Drug Therapy №2
俄罗斯联邦, Rostov-on-Don参考
- Rosendaal FR, Reitsma PH. Genetics of venous thrombosis. Journal of Thrombosis and Haemostasis. 2009;Suppl. 1:301-4. doi: 10.1111/j.1538-7836.2009. 03394.x
- Naess IA, Christiansen SC, Romundstad P, et al. Incidence and mortality of venous thrombosis: a population-based study. Journal of Thrombosis and Haemostasis. 2007;5(4):692-9. doi: 10.1111/j.1538-7836.2007.02450.x
- Kyrle PA, Minar E, Bialonczyk C, et al. The risk of recurrent venous thromboembolism in men and women. N Engl J Med. 2004;350(25):2558-63. doi: 10.1056/NEJMoa032959
- Vorobev AV, Makatsaria AD, Chabrov AM, et al. Pathogenesis of Trousseau’s syndrome. Journal of Obstetrics and Woman’s Diseases. 2015;64(4):85-94. (In Russ).
- Falanga A, Marchetti M. Hemostatic biomarkers in cancer progression. Thrombosis Research. 2018;164 (Suppl 1):S54-S61. doi: 10.1016/j.thromres.2018.01.017
- Cronin-Fenton DP, Sondergaard F, Pedersen LA, et al. Hospitalisation for venous thromboembolism in cancer pa-tients and the general population: a population-based cohort study in Denmark, 1997-2006. British Journal of Can-cer. 2010;103(7):947-53. doi: 10.1038/sj.bjc.6605883
- Chew HK, Wun T, Harvey D, et al. Incidence of venous thromboembolism and its effect on survival among patients with common cancers. Archives of Internal Medicine. 2006;166(4):458-64. doi:10.1001/ archinte.166.4.458
- Francis CW, Kessler CM, Goldhaber SZ, et al. Treatment of venous thromboembolism in cancer patients with dalte-parin for up to 12 months: the DALTECAN study. Journal of Thrombosis and Hae-mostasis. 2015;13(6):1028-35. doi: 10.1111/jth.12923
- Horsted F, West J, Grainge MJ. Risk of venous thromboembolism in patients with cancer: a systematic review and meta-analysis. PLoS Medicine. 2012;9 (7):e1001275. doi: 10.1371/journal.pmed.1001275
- Li M, Guo Q, Hu W. Incidence, risk factors, and out comes of venous thromboembolism after oncologic surgery: A systematic review and meta-analysis. Thrombosis Research. 2019;173:48-56. doi: 10.1016/j.thromres.2018.11.012
- Lee AY, Peterson EA. Treatment of cancer-associated thrombosis. Blood. 2013;122(14):2310-7. doi: 10.1182/blood-2013-04-460162
- Timp JF, Braekkan SK, Versteeg HH, et al. Epidemiology of cancer-associated venous thrombosis. Blood. 2013;122(10):1712-23. doi: 10.1182/blood-2013-04-460121
- Vossen CY, Hoffmeister M, Chang-Claude JC, et al. Clotting factor gene polymorphisms and colorectal cancer risk. Journal of Clinical Oncology. 2011;29(13):1722-7. doi: 10.1200/JCO.2010.31.8873
- Tinholt M, Viken MK, Dahm AE, et al. Increased coagulation activity and genetic polymorphisms in the F5, F10 and EPCR genes are associated with breast cancer: a case-control study. BMC Cancer. 2014;14:845. doi: 10.1186/1471-2407-14-845
- Blom JW, Doggen CJ, Osanto S, et al. Malignancies, prothrombotic mutations, and the risk of venous thrombosis. JAMA. 2005;293(6):715-22. doi:10.1001/ jama.293.6.715
- Vorobev AV, Chabrov AM, Savchenko AA., et al. Pathogenesis of Trousseau's syndrome. Obstetrics, Gynecology and Reproduction. 2015;9(2):99-109. (In Russ). doi: 10.17749/2070-4968.2015.9.2.099-109
- Smigielski EM, Sirotkin K, Ward M, et al. dbSNP: a database of single nucleotide polymorphisms. Nucleic Acids Re-search. 2000;28(1):352-5. doi:10. 1093/nar/28.1.352
- Kit OI, Katelnitskaya OV, Guskova NK, et al. Experience with the treatment of venous thromboembolism in oncolo-gy patients with the use of dabigatran. Flebologiya. 2016;10(1):29-34. (In Russ). doi: 10.17116/flebo201610129-34
- Strozenko LA, Gordeev VV, Lobanov YF, et al. Frequency of carriage of the polymorphic gene variants of clotting factors in adolescents in Barnaul. Siberian Medical Review. 2015;(3):53-6. (In Russ).
- Lobastov KV, Barinov VE, Schastlivtsev IV, et al. Sovremennye podkhody k diagnostike i terapii ostrogo venoznogo tromboza. Moscow: Triumf; 2016. (In Russ).
- Pizova NV. Trombofilii: geneticheskie polimorfizmy i sosudistye katastrofy. Moscow: IMA-PRESS; 2013. (In Russ).
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