电邮这篇文章 原发性膝关节置换术后内支架不稳定患者骨代谢状态和细胞因子分布变化的比较分析
- 作者: Galashina E.1, Ulyanov V.1,2, Gladkova E.1, Shpinyak S.1, Bondarenko A.3
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隶属关系:
- Research Institute of Traumatology, Orthopedics and Neurosurgery of Saratov State Medical University named after V.I. Razumovsky
- Saratov Medical University REAVIZ
- Saratov State Medical University named after V.I. Razumovsky
- 期: 卷 28, 编号 1 (2020)
- 页面: 5-12
- 栏目: Original study
- URL: https://journals.rcsi.science/pavlovj/article/view/15259
- DOI: https://doi.org/10.23888/PAVLOVJ20202815-12
- ID: 15259
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目的：确定sRANKL及BMP-2水平之间IL1β、TNFa和IL4在血清的关系，并探讨它们在原发性膝关节置换术后内支架内不稳定的发病机制中的作用。
材料与方法：80例患者回顾性分为2组：第一组包括40例术后12个月内发生的骨溶解和无菌性膝关节不稳定的患者；第二组包括40例植入性炎症患者在原发性膝关节置换术后4周至12个月内发生； 对照组由20名器官捐献者组成。用酶免疫法测定血清中sRANKL的组成 (pg/ml，Biomedica，奥地利) ，BMP-2 (pg/ml，Ray Bio，美国) ，还有细胞因子—TNFα (pg/ml) ， IL1β (pg/ml) 和IL4 (pg/ml) (Vector-Best封闭式股份公司，新西伯利亚市，俄罗斯) 的含量。通过确定Spearman相关等级的R系数，对具有统计学意义的指标进行比较分析。
结果：在第一组患者中，术后1个月，sRANKL水平与BMP-2、TNFa和IL4浓度呈中强度正相关。12个月后，所研究的参数保持了正相关，但与IL4无关系。第二组患者术后1个月sRANKL与BMP-2、TNFa呈中度负相关。12个月后，sRANKL的平均强度与BMP-2呈负相关关系，此外，出现了新的稳健关系：负的—BMP-2与IL1β，正的—sRANKL与IL1β和TNFα，IL1β和IL4。
结论：据记载，破坏种植体周围骨组织的代谢过程，激活破骨细胞形成的促炎细胞因子占主导地位，可能是原发性膝关节置换术后患者内支架不稳定形成的致病因素。
作者简介
Elena Galashina
Research Institute of Traumatology, Orthopedics and Neurosurgery of Saratov State Medical University named after V.I. Razumovsky
编辑信件的主要联系方式.
Email: sar.konf.sent@mail.ru
ORCID iD: 0000-0001-6209-9120
SPIN 代码: 4016-0672
PhD in Biological Sciences, Junior Researcher of the Department of Fundamental
俄罗斯联邦, SaratovVladimir Ulyanov
Research Institute of Traumatology, Orthopedics and Neurosurgery of Saratov State Medical University named after V.I. Razumovsky; Saratov Medical University REAVIZ
Email: v.u.ulyanov@gmail.com
ORCID iD: 0000-0002-9466-8348
SPIN 代码: 8280-3339
Researcher ID: A-4073-2014
MD, PhD, Deputy Director for Science and Innovations; Professor of the Department of Surgical Diseases
俄罗斯联邦, SaratovEkaterina Gladkova
Research Institute of Traumatology, Orthopedics and Neurosurgery of Saratov State Medical University named after V.I. Razumovsky
Email: gladkowa.katya@yandex.ru
ORCID iD: 0000-0002-6207-2275
SPIN 代码: 3837-3244
PhD in Biological Sciences, Head of the Department of Fundamental, Clinical and Experimental Researches
俄罗斯联邦, SaratovSergey Shpinyak
Research Institute of Traumatology, Orthopedics and Neurosurgery of Saratov State Medical University named after V.I. Razumovsky
Email: sergos83@rambler.ru
ORCID iD: 0000-0002-0345-6287
SPIN 代码: 6540-1764
MD, PhD, Junior Researcher of the Department of Innovative Projects for Traumatology and Orthopedics
俄罗斯联邦, SaratovAleksandr Bondarenko
Saratov State Medical University named after V.I. Razumovsky
Email: sar.konf.sent@mail.ru
ORCID iD: 0000-0001-6345-1851
SPIN 代码: 6719-4520
Deputy Dean of the General Medicine and Clinical Psychology Departments
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