Blood glucose level in rats with different behavioral activity in the dynamics of repeated stress exposures

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Aim. To study the effect of repeated stress on blood glucose level in rats with various behavioral characteristics and with different resistance to the development of adverse consequences of negative emotiogenic exposures.

Materials and Methods. The animals were initially subjected to open field test to calculate the index of activity. Daily 4-h immobilization of rats in individual plastic cages for 8 days was used as a model of stress. Blood glucose concentration was measured with a glucometer (control measurement and on the 1st, 3rd and 8th days of repeated stress).

Results. The basal level of glucose in behaviorally active (stress-resistant) rats was lower than in passive (stress-predisposed) specimens. Repeated exposure of rats to stress resulted in development of hyperglycemia. However, the dynamics of blood glucose concentration was different in specimens with different parameters of behavior. The increase in glucose concentration in active animals was most pronounced after a single exposure. By the 3rd and 8th days of stress exposures, glucose level in these rats progressively decreased (as compared to the 1st day), but remained above the basal level. Passive specimens were characterized by the increase in blood glucose concentration after a single and, particularly, after three-time restraint stress. Glucose content in these animals slightly decreased by the 8th day (as compared to the previous periods), but was above the basal level.

Conclusion. The dynamics of abnormalities in carbohydrate metabolism (in particular, changes in blood glucose level) during chronic emotiogenic exposures differed in specimens with different resistance to stress factors. These data illustrate the importance of an indivi-dual approach to studying the pathophysiological mechanisms of progression and development of stress-induced disorders.

作者简介

Anastasiya Abramova

Anokhin Research Institute of Normal Physiology; Moscow State University of Medicine and Dentistry named after A.I. Evdokimov

Email: s.pertsov@mail.ru
ORCID iD: 0000-0001-5940-3056
SPIN 代码: 1790-3941
Researcher ID: E-4592-2018

Senior Researcher of the Laboratory of Systemic Mechanisms of Emotional Stress; Senior Lecturer of the Department of Normal Physiology and Medical Physics

俄罗斯联邦, P.O.B. 72, 125315 Moscow, Russia; 20/1, Delegatskaya street, Moscow, 127473

Elena Koplik

Anokhin Research Institute of Normal Physiology

Email: s.pertsov@mail.ru
ORCID iD: 0000-0003-3898-8133
SPIN 代码: 3890-3334
Researcher ID: E-4802-2018

Leading Researcher of the Laboratory of Systemic Mechanisms of Emotional Stress

俄罗斯联邦, P.O.B. 72, 125315 Moscow, Russia

Irina Alekseyeva

Anokhin Research Institute of Normal Physiology

Email: s.pertsov@mail.ru
ORCID iD: 0000-0001-9236-5143
SPIN 代码: 3539-5592
Researcher ID: E-4837-2018

Research Laboratory Assistant of the Laboratory of Systemic Mechanisms of Emotional Stress

俄罗斯联邦, P.O.B. 72, 125315 Moscow, Russia

Sergey Pertsov

Anokhin Research Institute of Normal Physiology; Moscow State University of Medicine and Dentistry named after A.I. Evdokimov

编辑信件的主要联系方式.
Email: s.pertsov@mail.ru
ORCID iD: 0000-0001-5530-4990
SPIN 代码: 3876-0513
Researcher ID: A-6697-2017

MD, PhD, Professor, Corresponding Member of RAS, Deputy Director for Research, Head of the Laboratory of Systemic Mechanisms of Emotional Stress; Head of the Department of Normal Physiology and Medical Physics

俄罗斯联邦, P.O.B. 72, 125315 Moscow, Russia; 20/1, Delegatskaya street, Moscow, 127473

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版权所有 © Abramova A.Y., Koplik E.V., Alekseyeva I.V., Pertsov S.S., 2019

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