Характеристика гликопротеина-р как белка транспортера лекарственных веществ

Обложка

Цитировать

Полный текст

Аннотация

В обзоре литературы охарактеризованы актуальность проблемы, химические свойства субстратов гликопротеина-Р, структура, функции, локализация транспортера, факторы, влияющие на активность гликопротеина-Р.

Список литературы

  1. Значение полиморфизма гена MDR1, кодирующего гликопротеин-P, для индивидуализации фармакотерапии / Д.А. Сычев [и др.] // Клинич. фармакология и терапия. – 2005. – №1. – С. 92-96.
  2. Карпова С.И. P-гликопротеин – структура, функции и роль в резистентности лейкозов к химиотерапии / С.И. Карпова, Н.Г. Тюрина // Пробл. гематологии и переливания крови. – 1997. – №1. – С. 37-46.
  3. Метаболизм лекарственных средств. Научные основы персонализированной медицины: руководство для врачей / В.Г. Кукес [и др.]. – М.: ГЭОТАР-Медиа, 2008. – 304 с.
  4. Токсикологическая химия. Метаболизм и анализ токсикантов: учебное пособие / Е.Ю. Афанасьева [и др.]; под ред. Н.И. Калетиной. – М.: ГЭОТАР-МЕДИА, 2008. – С. 149-164.
  5. Acidosis induces multi-drug resistance in rat prostate cancer cells (AT1) in vitro and in vivo by increasing the activity of the p-glycoprotein via activation of p38 / C. Sauvant [et al.] // Int J Cancer. – 2008. – Vol. 123, №11. – P. 2532-2542.
  6. Activation of P-glycoprotein (Pgp)-mediated drug efflux by extracellular acidosis: in vivo imaging with (68)Ga-labelled PET tracer / O. Thews [et al.] // Eur J Nucl Med Mol Imaging. – 2010. – Vol. 37, №10. – P. 1935-1942.
  7. Animal models of acute moderate hypoxia are associated with a down-regulation of CYP1A1, 1A2, 2B4, 2C5, and 2C16 and up-regulation of CYP3A6 and P-glycoprotein in liver / C. Fradette [et al.] // Drug Metab Dispos. – 2007. –Vol. 35, №5. – P. 765-771.
  8. Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues / F. Thiebaut [et al.] // Proc Natl Acad Sci U S A. – 1987. – Vol. 84, №21. – P. 7735-7738.
  9. Chaudhary P.M. Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells / P.M. Chaudhary, I.B. Roninson // Cell. – 1991. – Vol. 66, №1. – P. 85-94.
  10. Choudhuri B.S. Isoniazid accumulation in Mycobacterium smegmatis is modulated by proton motive force-driven and ATP-dependent extrusion systems / B.S. Choudhuri, S. Sen, P. Chakrabarti // Biochem Biophys Res Commun. – 1999. – Vol. 256, №3. – P. 682-684.
  11. Doxorubicin induces drug efflux pumps in Candida albicans / G. Kofla [et al.] // Med Mycol. – 2011. – Vol. 49, №2. – P. 132-142.
  12. Effect of levothyroxine administration on intestinal P-glycoprotein expression: consequences for drug disposition / W. Siegmund [et al.] // Clin. Pharmacol. Ther. – 2002. – Vol. 72. – P. 256-264.
  13. Effects of genetic polymorphisms in the ABCB1 gene on clinical outcomes in patients with gastric cancer treated by second-line chemotherapy / K. Shitara [et al.] // Asian Pac J Cancer Prev. – 2010. – Vol. 11, №2. – P. 447-452.
  14. Expression and significance of hypoxia-inducible factor-1 alpha and MDR1/P-glycoprotein in human colon carcinoma tissue and cells / Z.J. Ding [et al.] // Cancer Res Clin Oncol. – 2010. – №3. – P. 1276-1282.
  15. Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues / C.J. Cordon-Cardo [et al.] // Histochem Cytochem. – 1990. – Vol. 38, №9. – P. 1277-1287.
  16. Guhaniyogi J. Regulation of mRNA stability in mammalian cells / J. Guhaniyogi, G. Brewer // Gene. – 2001. – Vol. 265, №1. – P. 11-23.
  17. Horio M. ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells / M. Horio, M.M. Gottesman, I. Pastan // Proc Natl Acad Sci U S A. – 1988. – Vol. 85, №10. – P. 3580-3584.
  18. Human multidrug resistance-1 gene expression levels in graves-basedow disease / S. Cetinkalp [et al.] // Exp. Clin. Endocrinol. Diabetes. – 2010. –Vol. 118, № 3. – P. 158-160.
  19. Hypoxia induces resistance to 5-fluorouracil in oral cancer cells via G(1) phase cell cycle arrest / S. Yoshiba [et al.] // Oral Oncol. – 2009. – Vol. 45, №2. – P. 109-115.
  20. Hypoxia-inducible Factor-1-dependent Regulation of the Multidrug Resistance (MDR1) Gene / M. Katrina [et al.] // Cancer Res. – 2002. – №6. – P. 3387.
  21. Identification of P-glycoprotein substrates and inhibitors among psychoactive compounds-implications for pharmacokinetics of selected substrates / A.A. El Ela [et al.] // J Pharm Pharmacol. – 2004. – Vol. 56, №8. – P. 967-975.
  22. Influence of intermittent hypoxia on myocardial and hepatic P-glycoprotein expression in a rodent model / J.M. Dopp [et al.] // Pharmacotherapy. –2009. – Vol. 29, №4. – P. 365-372.
  23. Influence of Intermittent Hypoxia on Myocardial and Hepatic P-glycoprotein Expression / M. John [et al.] // Pharmacotherapy. – 2009. – Vol. 29, №4. – P. 365-372.
  24. Levothyroxine up-regulates p-glycoprotein independent of the pregnane-X-receptor / Т. Mitin [et al.] // Physiol. Rev. – 2006. – Vol. 86. – P. 1179-1236.
  25. Linlin Su Drug transporter, P-glycoprotein (MDR1), is an integrated component of the mammalian blood-testis barrier / C. Yan Cheng, Dolores D. Mruk // Int J Biochem Cell Biol. – 2009. – Vol. 41, №12. – P. 2578-2587.
  26. Mitchell A. Thyroid hormone export from cells: contribution of P-glycoprotein / A. Mitchell, M. Tom, R. Mortimer // Endocrinol. – 2005. – Vol. 185, № 1. – P. 93-98.
  27. Modulation of P-glycoprotein expression in hyperthyroid rat tissues / N. Nishio [et al.] // Journal of endocrinology. – 2005. – Vol. 185. – P. 93-98.
  28. N-glycosylation and deletion mutants of the human MDR1 P-glycoprotein / A.H. Schinkel [et al.] // J Biol Chem. – 1993. – Vol. 268, №10. – P. 7474-7481.
  29. O’Connor P. Clinical pharmacokinetics and endocrine disorders – therapeutic implication / P. O’Connor, J. Feely // Clin. Pharmacokinet. – 1987. – №13. – P. 435-364.
  30. P-Glycoprotein (ABCB1) expression in human skin is mainly restricted to dermal components / C. Skazik [et al.] // Exp Dermatol. – 2011. – №3. – Р. 1600-1625.
  31. Rifampin and digoxin induction of MDR1 expression and function in human intestinal (T84) epithelial cells / I.S. Haslam [et al.] // Br J Pharmacol. – 2008. – Vol. 154, №1. – P. 246-255.
  32. Role of the tumor microenvironment in the activity and expression of the p-glycoprotein in human colon carcinoma cells / C. Lotz [et al.] // Oncol Rep. – 2007. – Vol. 17, №1. – P. 239-244.
  33. Schlachetzki F. P-glycoprotein and caveolin-1alpha in endothelium and astrocytes of primate brain / F. Schlachetzki, W.M. Pardridge // Neuroreport. – 2003. – Vol. 14, №16. – P.2041-2046.
  34. Subpopulations of normal peripheral blood and bone marrow cells express a functional multidrug resistant phenotype / D. Drach [et al.] // Blood. – 1992. – Vol. 80, №11. – P. 2729-2734.
  35. Targeting multidrug resistance in cancer / G. Szakács [et al.] // Nat Rev Drug Discov. – 2006. – Vol. 5, №3. – P. 219-234.
  36. The Impact of Thyroid Disease on the Regulation, Expression, and Function of ABCB1 (MDR1/P Glycoprotein) and Consequences for the Disposition of Digoxin / O. Burk [et al.] // Clin Pharmacol Ther. – 2010. – Vol. 88, №5. – P. 685-694.
  37. The importance of a nitrogen atom in modulators of multidrug resistance / G. Ecker [et al.] // Mol Pharmacol. – 1999. – Vol. 56, №4. – P. 791-796.
  38. The molecular biology of thyroid hormone action / R.C.J. Reibeiro [et al.] // Ann NY Acad Sci. – 1995. – Vol. 758. – P. 366-389.
  39. The structure and functions of P-glycoprotein / Y. Li [et al.] // Curr Med Chem. – 2010. – Vol. 17, №8. – P. 786-800.
  40. Thyroid hormone export in rat FRTL-5 thyroid cells and mouse NIH-3T3 cells is carrier-mediated, verapamil-sensitive, and stereospecific / R. Cavalieri [et al.] // Endocrinology. – 1999. – Vol. 140. – P. 4948-4954.
  41. Thyroxine (T4) transfer from CSF to choroid plexus and ventricular brain regions in rabbit: contributory role of P-glycoprotein and organic anion transporting polypeptides / N. Kassem [et al.] // Brain Res. – 2007. – Vol. 1181. – P. 44-50.
  42. Ueda K. Isolation and sequence of the promoter region of the human multidrug-resistance (P-glycoprotein) gene / K. Ueda, I. Pastan, M.M. Gottesman // J Biol Chem. – 1987. – Vol. 262, №36. – P. 17432-17436.

© Якушева Е.Н., Черных И.В., Бирюкова А.С., 2011

Creative Commons License
Эта статья доступна по лицензии Creative Commons Attribution 4.0 International License.
 


Данный сайт использует cookie-файлы

Продолжая использовать наш сайт, вы даете согласие на обработку файлов cookie, которые обеспечивают правильную работу сайта.

О куки-файлах