Analysis and Evaluation of Modern Approaches to Development of Medical Drugs Using Micro- and Nanotechnologies
- Authors: Raguzin E.V.1, Yudin M.A.1, Glushenko D.D.1, Vengerovich N.G.1, Raguzina O.G.1, Pechurina T.B.1, Shefer T.V.1, Ivanov I.M.1
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Affiliations:
- State Research and Testing Institute of Military Medicine
- Issue: Vol 30, No 3 (2022)
- Pages: 397-410
- Section: Reviews
- URL: https://journals.rcsi.science/pavlovj/article/view/104787
- DOI: https://doi.org/10.17816/PAVLOVJ104787
- ID: 104787
Cite item
Abstract
INTRODUCTION: TDespite the achievements of the modern medicine, use of some medical drugs (MDs) is associated with both the absence of a significant therapeutic effect due to peculiarities of the physico-chemical interaction in the internal environment of an organism, and with the adverse effect on organs and tissues. The advanced technologies of creation of micro- and nanoparticles will permit to improve pharmacokinetics and pharmacodynamics of the drug, its bioavailability and solubility, the ability of crossing blood-brain barriers, and to reduce undesirable systemic effects. MDs using micro- and nanoparticles, have a targeted effect on the focus of pathological lesion. An important additional advantage is a possibility of using micro- and nanoparticles in development of long-acting MDs. The main active substances immobilized to micro- and nanoparticles, open up new prospects for effective treatment of different pathological conditions (neoplasms, diseases of cardiovascular and central nervous system, inflammatory processes, wounds), and for realization of new imaging capabilities in foci of a pathological process, which is especially important in diagnostic procedures.
CONCLUSION: The article presents a summary of the ideas of methods of micro- and nanoencapsulation, and assessments of the prospects for the development of drugs for the correction of pathological conditions using innovative technologies.
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##article.viewOnOriginalSite##About the authors
Evgeniy V. Raguzin
State Research and Testing Institute of Military Medicine
Email: evgeny.raguzin@yandex.ru
ORCID iD: 0000-0002-1707-6912
SPIN-code: 8524-3195
MD, Cand. Sci (Med.)
Russian Federation, Saint-PetersburgMikhail A. Yudin
State Research and Testing Institute of Military Medicine
Email: mikhail.judin@gmail.com
ORCID iD: 0000-0001-5646-0880
SPIN-code: 4763-9666
MD, Dr. Sci. (Med.), Associate Professor
Russian Federation, Saint-PetersburgDaniil D. Glushenko
State Research and Testing Institute of Military Medicine
Author for correspondence.
Email: glushenko.daniil.d@yandex.ru
ORCID iD: 0000-0001-9425-6565
SPIN-code: 2934-6129
Kursant fourth course. Third faacultet
Russian Federation, Saint-PetersburgNikolay G. Vengerovich
State Research and Testing Institute of Military Medicine
Email: Gniiivm_15@mil.ru
ORCID iD: 0000-0003-3219-341X
SPIN-code: 6690-9649
MD, Dr. Sci. (Med.)
Russian Federation, Saint-PetersburgOl’ga G. Raguzina
State Research and Testing Institute of Military Medicine
Email: Raguzinaog@yandex.ru
ORCID iD: 0000-0002-2139-1376
SPIN-code: 6038-3008
Russian Federation, Saint-Petersburg
Tat’yana B. Pechurina
State Research and Testing Institute of Military Medicine
Email: tat79@list.ru
ORCID iD: 0000-0002-8228-2800
SPIN-code: 7890-4203
Cand. Sci (Tech.)
Russian Federation, Saint-PetersburgTimur V. Shefer
State Research and Testing Institute of Military Medicine
Email: 79043315812@yandex.ru
ORCID iD: 0000-0001-7303-0591
SPIN-code: 8739-8385
MD, Dr. Sci. (Med.)
Russian Federation, Saint-PetersburgIgor’ M. Ivanov
State Research and Testing Institute of Military Medicine
Email: igor611ivanov@gmail.com
ORCID iD: 0000-0002-8708-8484
SPIN-code: 1518-3306
MD, Cand. Sci (Med.)
Russian Federation, Saint-PetersburgReferences
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