Fibronectin, hemostasis and phagocytosis

Abstract

On the basis of experimental and literature data a hypothesis is proposed that plasma fibronectin serves as a mediator between hemostasis and RES. Fibronectin is thought to be an opsonic factor in the elimination of throm- bogenic particles from blood flow. As an example of thrombogenic particles soluble fibrin precursors covalently bound to plasma fibronectin are examined. Interrelated chages of plasma fibronectin level, DIC signes, and alterations of the Kupffer cells’ morphologic- and-functional state are in favor of the hypothesis. The idea is also proved by the presence of specific protein receptors for fibronectin on the surface of mononuclear phagocytes and neutrophils. It is suggested that plasma fibronectin and phagocytes represent a united antithrombotic mechanism which prevents excessive intravascular activation of hemostatic system in pathology.

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