Changes of the structure of neuron, glial cells and capillaries in audiogenic epilepsy

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Abstract

The changes of components of neuron — glia — capillar system in sensorimotor cortex of rats in 1, 12 and 24 hours after one and four audiogenic seizures are investigated by luminous and partly electronic microscopy methods. The changes of neurons, their dendrites, glial cells and vessels with elements of reparative character are discovered. During postseizure period the intracellular structure of neurons rocovers earlier then the structure of dendrites. The separate neurons undergo irreversible destruction in the presence of glial cells hyperplasia, vascular disorders retain.

About the authors

E. N. Popova

Laboratory of Brain Ultrastructure of the Research Institute of the Russian Academy of Medical Sciences

Author for correspondence.
Email: info@eco-vector.com
Russian Federation, Moscow

F. A. Yakhin

Laboratory of Brain Ultrastructure of the Research Institute of the Russian Academy of Medical Sciences

Email: info@eco-vector.com
Russian Federation, Moscow

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2. Fig. 1. Ultrastructure of layer V sensorimotor cortex neuron one hour after one audiogenic seizure, x 12000.

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3. Fig. 2. Vessel dystonia, endothelial nuclei nyknosis, and perivascular edema in layer V of the sensorimotor cortex one hour after 4 audiogenic seizures. Nissl staining. x 400.

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4. Рис. 3. Варикозные изменения базальных дендритов нейрона в слое V сенсомоторной коры через 24 часа после четырехкратных аудиогенных припадков. Окраска по Гольджи. х 150.

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