Microvesiculation in immunoconflict pregnancy and hemolytic disease of newborns

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Abstract

The microvesiculation process of cell membranes increases in blood of women during pregnancy development. In women with Rh-conflict pregnancy the course of the microvesiculation process is more intensive than in physiologic pregnancy. In intratubal affection of the fetus by hemolytic disease (the congenital icteric form) the microvesiculation process increases sharply in blood seram parallel to the increase of unconjugated bilirubin level. The determination of 5’-nucleotidase activity in hemolytic disease of newborns can be used as an additional diagnosis method of microvesiculation in this pathologic state.

About the authors

А. F. Subkhankulova

Kazan State Medical University

Author for correspondence.
Email: info@eco-vector.com

Department of Biochemistry, Department of Obstetrics and Gynecology No. 2

Russian Federation, Kazan

D. M. Zubairov

Kazan State Medical University

Email: info@eco-vector.com

Academician of the Academy of NT, Professor, Head of the Department of Biochemistry, Department of Obstetrics and Gynecology No. 2

 
Russian Federation, Kazan

F. B. Subkhankulova

Kazan State Medical University

Email: info@eco-vector.com

Department of Biochemistry, Department of Obstetrics and Gynecology No. 2

Russian Federation, Kazan

B. G. Sadykov

Kazan State Medical University

Email: info@eco-vector.com

Department of Biochemistry, Department of Obstetrics and Gynecology No. 2

Russian Federation, Kazan

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1. JATS XML
2. Fig. 1. Intensity of microvesiculation (activity of the marker enzyme 5'-nucleotidase) in blood serum during physiological and resus-conflict pregnancy by trimester.

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3. Fig. 2. The ratio of the level of bilirubin (μmol / l) and the activity of 5'-nucleotidase (nkat / l) in the umbilical cord blood of newborns with different outcomes of childbirth.

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© 1998 Subkhankulova А.F., Zubairov D.M., Subkhankulova F.B., Sadykov B.G.

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