Pathomorphological changes in the placenta, umbilical cord and membranes during late toxicosis of pregnancy

In 1900, K.P. Ulezko-Strogonova found macroscopically the presence of white infarctions in the placenta with eclampsia, and microscopic examination of villous necrosis, poor development of the Nitabuch layer, sclerosis of the villous stroma, thickening of the vascular wall, swelling and hyperplasia of syncytial cells, vasodilatation villi, overflow with blood, fibrinoid necrosis and the formation of new villi. RF Brodsky (1950) describes edema of villi, desolation of capillaries and degeneration of syncytial epithelium. 3. F. Drobenya (1955) and F. Gregor (1961) describe hyalinosis of the stroma and vessels of the villi, edema of the media and proliferation of the vascular intima. O. N. Shirokinskaya (1957) and I.A. Guryanova (1957) with nephropathy and eclampsia found an overgrowth of the connective tissue of the stroma of the villi and vascular walls, their closure, thrombosis of intervillous spaces, extensive edema and infarction of villi, their overflow with blood and necrosis.