The properties and role of tumor necrosis factor alpha in the pathogenesis of HIV infection

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Abstract

This review presents the current understanding regarding the tumor necrosis factor alpha: its origin, receptors, main properties and its role in the pathogenesis of HIV infection (the infection, caused by the Human Immunodeficiency Virus). Tumor necrosis factor alpha induces viral replication in CD4+ T lymphocytes, monocytes and macrophages, promotes death of uninfected CD4+ T lymphocytes as well as CD8+ by the mechanism of apoptosis, allowing the progression of immunodeficiency. Tumor necrosis factor alpha maintains the viability of infected CD4+ T lymphocytes, contributing to the formation of the viral reservoir in the patient. Elevated levels of the tumor necrosis factor alpha in the blood plasma of HIV-infected individuals should be regarded as a marker of disease progression.

About the authors

P D Dunaev

Kazan State Medical University, Kazan, Russia

Email: dunaevpavel@mail.ru

S V Boychuk

Kazan State Medical University, Kazan, Russia

I G Mustafin

Kazan State Medical University, Kazan, Russia

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© 2012 Dunaev P.D., Boychuk S.V., Mustafin I.G.

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