Major histocompatibility complex genetic variants in potential hematopoietic stem cells donors in Republic of Kazakhstan
- Authors: Burkitbaev Z.K1, Raisov SD1, Turganbekova AA1, Ramil’eva IR1, Yakiyaeva DU1, Baymukasheva DK1, Abdrakhmanova SA1, Zhiburt EB2
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Affiliations:
- Research and Production Center of Transfusiology of Republic of Kazakhstan, Astana, Kazakhstan
- National Medical and Surgical Centre named after N.I. Pirogov, Moscow, Russia
- Issue: Vol 96, No 3 (2015)
- Pages: 417-425
- Section: Transfusiology of the XXI century: problems, goals, future perspectives
- URL: https://journals.rcsi.science/kazanmedj/article/view/1677
- DOI: https://doi.org/10.17750/KMJ2015-417
- ID: 1677
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Abstract
Aim. To compare the prevalence of HLA-system antigens genetic variants in potential hematopoietic stem cells donors in Kazakhstan and worldwide.
Methods. Prevalence of HLA-antigens genetic variants in blood samples of potential hematopoietic stem cells donors included in hematopoietic stem cells donors register of Kazakhstan was analyzed and compared to a «Allele frequencies in Worldwide populations» database developed by the Royal Liverpool University Hospital.
Results. The biggest overlap of Kazakhstan and World registers was seen in the distribution of 31-01 allele: 68 (4.5%) in Kazakhstan register, 1678 (4.63%) worldwide; odds ratio (OR) = 0.97 (0.76 to 1.24), F=0.851441, χ2=0.06. The biggest difference between the two registers was found in the distribution of locus A antigens: A 02-01 (χ2=24.59), A 02-07 (χ2=24.42), A 32-01 (χ2=27.1), A 02-37 (χ2=23.96), A 11-38 (χ2=3.96). In locus B alleles, the biggest overlap between the two comparison groups was in В 14:02 allele: Kazakhstan register - 31 (2.05%), worldwide register - 757 (2.01%) [OR=1.02 (0.71 to 1.47), F=0.851990, χ2=0.01], followed by 38:02 (χ2=0.02), 44:05 (χ2=0.03), in 27:07 (χ2=0.04), 54:01 (χ2=0.07). The biggest difference between the two registers was in 13:02 (χ2=256.9), 08:01 (χ2=26.92) locus B alleles. Distribution of locus C alleles was discovered to have the biggest statistical similarity of two registers provided by C 07:01 (χ2=0.07), 08:02 (χ2=0.15), 15:02 (χ2=0.23) 12:03 (χ2=0.76). The biggest difference in the distribution of locus C alleles between the two registers was in 06:02 (χ2=125.78) and C 03:02 (χ2=103.64).
Conclusion. The overlap of HLA-antigens genetic variants distribution in Kazakhstan and global registers varies from 41 to 52% by loci (locus A - 50%, B - 52%, C - 48%, DRB1 - 51%, DQB1 - 41%, mean 48.4%, median 50%). Kazakhstan register contains information on unique HLA-antigens genetic variants not included in the general database, manifesting the need for national register development and its integration into the «Allele frequencies in Worldwide populations» register.
About the authors
Zh K Burkitbaev
Research and Production Center of Transfusiology of Republic of Kazakhstan, Astana, Kazakhstan
Author for correspondence.
Email: raissovs@mail.ru
S D Raisov
Research and Production Center of Transfusiology of Republic of Kazakhstan, Astana, Kazakhstan
Email: raissovs@mail.ru
A A Turganbekova
Research and Production Center of Transfusiology of Republic of Kazakhstan, Astana, Kazakhstan
Email: raissovs@mail.ru
I R Ramil’eva
Research and Production Center of Transfusiology of Republic of Kazakhstan, Astana, Kazakhstan
Email: raissovs@mail.ru
D U Yakiyaeva
Research and Production Center of Transfusiology of Republic of Kazakhstan, Astana, Kazakhstan
Email: raissovs@mail.ru
D K Baymukasheva
Research and Production Center of Transfusiology of Republic of Kazakhstan, Astana, Kazakhstan
Email: raissovs@mail.ru
S A Abdrakhmanova
Research and Production Center of Transfusiology of Republic of Kazakhstan, Astana, Kazakhstan
Email: raissovs@mail.ru
E B Zhiburt
National Medical and Surgical Centre named after N.I. Pirogov, Moscow, Russia
Email: raissovs@mail.ru
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