Glutathione detoxication processes in females suffering from sterility

Thirty females suffering from sterility were examined. Fertility disorders were accompanied by hyperandrogeny. Hormones FSH, LH, testosterone and progesterone in blood were studied. Besides, an activity of enzymes GPO, GTD, GST, G-6-PD in washed erythrocytes and tissue homogenate of ovary was investigated. Findings obtained demonstrate noticeable disorders in glutathione detoxication processes in females with infertility and they are related to hormones’ level, in particular androgens. An increase of GPO in females with hyperandrogeny showed deepupdates in metabolism processes of steroid hormones in ovary. It manifests beforehand for development of follicle that is predictive sign of unovulation in the beginning of menstrual cycle.