Research of genetic predisposition to gestosis: polymorphism of genes, participating in vasoregulation of functions endothelium

The polymorphism of the genes involved in the regulation of endothelial function - PLAT, PAI-1, ACE, eNOS and TNF-α - was studied in 122 pregnant women with pure and concomitant preeclampsia of varying severity and in 73 healthy puerperas. It was revealed that mutant genotypes of the studied genes are associated with more pronounced clinical and laboratory indicators of the severity of preeclampsia and the greatest increase in the level of markers of endothelial dysfunction. It is noted that the frequency of mutant genes and alleles varies depending on the severity of preeclampsia and the presence of background diseases characterized by the presence of endothelial dysfunction. The data obtained confirm the opinion that gestosis is a multifactorial disease with several, possibly independent, developmental pathways. The study of the polymorphism of genes regulating endothelial function contributes to the early identification of a risk group for the development of preeclampsia.