On the model of hormonal carcinogenesis on the example of uterine leiomyoma: problems and prospects

The main principles of progesterone hypothesis and the role of auto- and paracrine factors in uterine leiomyoma pathobiology are considered in the article. The necessity of early therapeutic intervention since humor detection is maintained with the aim of reproductive health recovery. The basic features of strategy in case of uterine leiomyoma are defined: measures due to be undertaken since humor detection, determination of limits and possibilities of adjuvant medicamental treatment and optimal time for surgery, conducting patients in peri- and postmenopause and evaluation of oncological risk.