The peculiarity of protein degradation under the pregnancy with gestosis and diabetes

Some groups of women with normal pregnancy with pregnaizcy aggravated by gestosis and diabetes I and II were examined. The level of middle molecules (MM) and protein peroxidation (PP) were measured in the blood serum. The activity of ceruloplasmin (CP) and oxitocinase (ОС) were evaluated too. The level of MM was measured in the urine. More active processes of protein degradation were shown under normal pregnancy in comparison with unpregnant group. These processes reflect both free radical reaction and proteolitic processes. Activation of proteolisis results in evaluated level of MM. The MM content and PP level were not increased significantly in the group with gestosis. But the elevated activity of ceruloplasmin (on 15%) under gestosis reflects an activation of «oxidative stress» and free radical processes. It was found an increased serum and decreased urine level of MM and in the group of women with complicated diabetes I. The women with diabetes II have shown elevated CP activity (on 14%) too and increased level of PP (on 14%). It was supposed that MM may be a toxic factor witch damage placenta and foetus under diabetes I and II. The free radicals may be a factor which hurt tissue of placenta and foetus under diabetes II.