电邮这篇文章 在预防过程中的智力缺陷：正常还是病理学？
- 作者: Bezmenko A.A.1, Sadovaya N.D.1
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隶属关系:
- Military Medical Academy named after S.M. Kirov
- 期: 卷 70, 编号 6 (2021)
- 页面: 5-12
- 栏目: Original study articles
- URL: https://journals.rcsi.science/jowd/article/view/70592
- DOI: https://doi.org/10.17816/JOWD70592
- ID: 70592
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详细
论证。近年来，随着分子遗传学诊断方法的积极发展，科学家们对肠道微生物区系的研究兴趣显著增加。一些科学论文已经确定了肠道微生物群在维持妊娠过程中的重要性，但关于这个问题的研究数量很少。
目的-评估孕妇肠道菌群的定性和定量组成。
材料与方法。这项研究涉及200名年龄在18至43岁之间、胎龄为6至22周的女性。所有孕妇均通过实时聚合酶链反应对肠道和阴道菌群状态进行定性和定量评估。
结果。在接受检查的孕妇中，100%检测到肠道菌群失调，而64.5%（n=129）的病例的菌群失调程度为I级，26.5%（n=53）为II级，9%（n=18）为III级。在所有孕妇中，常驻菌群对结肠的定植强度降低；此外，在中度和重度菌群失调的妇女中发现了条件致病菌Clostridium difficile，Enterobacter spp.， Streptococcus spp. 和 Campylobacter spp.，数量超过正式允许值。对妊娠过程的分析表明，肠道菌群失调II或III度是早期复杂妊娠的危险因素（OR=0.2；p=0.00），这证明了肠道菌群失调在流产中的作用。
结论。妊娠是肠道菌群变化的易感因素，100%的孕妇检测到肠道菌群失调就证明了这一点。考虑到大多数正常妊娠的妇女被诊断为1级肠道菌群失调，可以认为这种程度的微生物失调是妊娠的正常现象。中度或重度肠道失调与复杂的早孕有关。
作者简介
Alexandr A. Bezmenko
Military Medical Academy named after S.M. Kirov
Email: bezmenko@yandex.ru
ORCID iD: 0000-0003-2837-1260
SPIN 代码: 8739-9920
MD, Cand. Sci. (Med.)
俄罗斯联邦, Saint PetersburgNatalya D. Sadovaya
Military Medical Academy named after S.M. Kirov
编辑信件的主要联系方式.
Email: nataliacrimea@gmail.com
ORCID iD: 0000-0003-3362-4402
SPIN 代码: 7063-7367
俄罗斯联邦, Saint Petersburg
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