Экспериментальные модели сахарного диабета 1-го типа

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В настоящем обзоре рассмотрены основные методы моделирования сахарного диабета 1-го типа с использованием лабораторных животных. Обобщены данные литературы, связанные с представлениями о патогенезе развития клинической и морфологической картины заболевания, о возможности экстраполяции результатов, а также проанализированы преимущества и недостатки каждой из моделей. На основании представленных данных сделан вывод о необходимости проведения доклинических исследований в качестве фундаментальной базы для изучения сахарного диабета 1-го типа.

Об авторах

Мария Игоревна Ярмолинская

ФГБНУ «Научно-исследовательский институт акушерства, гинекологии и репродуктологии им. Д.О. Отта»; ФГБОУ ВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава России

Email: m.yarmolinskaya@gmail.com
SPIN-код: 3686-3605
Scopus Author ID: 489874

д-р мед. наук, профессор РАН, руководитель отдела эндокринологии репродукции, руководитель центра «Диагностика и лечение эндометриоза»; профессор кафедры акушерства и гинекологии

Россия, Санкт-Петербург

Нелли Юрьевна Андреева

ФГБНУ «Научно-исследовательский институт акушерства, гинекологии и репродуктологии им. Д.О. Отта»

Автор, ответственный за переписку.
Email: Nelly8352@yahoo.com

клинический ординатор

Россия, Санкт-Петербург

Елена Ивановна Абашова

ФГБНУ «Научно-исследовательский институт акушерства, гинекологии и репродуктологии им. Д.О. Отта»

Email: abashova@yandex.ru
SPIN-код: 2133-0310
Scopus Author ID: 252499

канд. мед. наук, старший научный сотрудник отдела эндокринологии репродукции

Санкт-Петербург

Елена Владимировна Мишарина

ФГБНУ «Научно-исследовательский институт акушерства, гинекологии и репродуктологии им. Д.О. Отта»

Email: mishellena@gmail.com

канд. мед. наук, старший научный сотрудник отдела эндокринологии репродукции

Россия, Санкт-Петербург

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