Генотоксические биомаркеры у пациентов, находящихся на гемодиалиазе

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Аннотация

Общепризнано, что генотоксические поражения имеют существенное этиопатогенетическое значение, а их предупреждение является важной мерой сохранения жизни и здоровья человека. В рамках этой концепции рассмотрены и обобщены литературные сведения об исследованиях генотоксических биомаркеров у пациентов с различными вариантами гемодиализа. На основе анализа известных данных сделано заключение, что пациенты этой группы имеют повышенный уровень повреждений ДНК и хромосом в лимфоцитах периферической крови. На основе результатов отдельных работ показано, что одной из стратегий уменьшения генотоксичности может быть совершенствование методов и режимов гемодиализной терапии, а также фармакологическая и нутрициологическая коррекция генотоксических эффектов.

Об авторах

Наталья Вахитовна Еремина

Федеральное государственное бюджетное научное учреждение «Научно-исследовательский институт фармакологии им. В.В. Закусова»

Автор, ответственный за переписку.
Email: neremina@panacelalabs.com
ORCID iD: 0000-0002-7226-5505
SPIN-код: 5224-1968

канд. биол. наук, старший научный сотрудник лаборатории лекарственной токсикологии

Россия, Москва

Андрей Дмитриевич Дурнев

Федеральное государственное бюджетное научное учреждение «Научно-исследовательский институт фармакологии им. В.В. Закусова»

Email: addurnev@mail.ru
ORCID iD: 0000-0003-0218-8580
SPIN-код: 8426-0380
Scopus Author ID: 7006060753
ResearcherId: S-7428-2016

д-р мед. наук, профессор, член-корреспондент РАН, директор института

Россия, Москва

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2. Рис. 1. Частота микроядер в лимфоцитах пациентов, находящихся на гемодиализной терапии, и контрольных групп, среднее ± SEM (n = 7, p < 0,05)

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3. Рис. 2. Корреляция частоты микроядер (МЯ) в двуядерных лимфоцитах у пациентов, проходящих гемодиализ, и контрольных групп. Каждая точка на графике представляет среднее значение для одного исследования (n = 7)

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