Распределение частот vntr аллелей локуса 5-httlpr гена транспортера серотонина в населении Евразии и Африки

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Для 21 популяции Евразии и Африки определены частоты аллеля S локуса 5-HTTLPR гена транспортера серотонина ассоциированного с рядом психологических особенностей человека. В тех же популяциях рассчитаны главные компоненты генетической изменчивости (PC1 и РС2) на основе опубликованных частот 68 предположительно нейтральных аллелей 5 STR-локусов системы CODIS. Частота аллеля S значимо коррелирует c PC2 (R = 0,820, p < 0,0001), то есть соответствует структуре общей генетической изменчивости этих популяций. Для 4 из 68 исследованных аллелей уровень корреляции частоты STR аллеля с индексом индивидуализма-коллективизма по Хофстеду даже выше, чем для аллеля S. Наши данные не подтверждают гипотезу (Chiao, Blizinsky, 2010) о ген-культурной коэволюции частоты аллеля S и уровня коллективизма.

Об авторах

Алексей Сергеевич Гуреев

Институт общей генетики им. Н. И. Вавилова РАН

Автор, ответственный за переписку.
Email: alexy31@yandex.ru
н. c. Лаб. анализа генома

Анна Александровна Ким

Институт общей генетики им. Н. И. Вавилова РАН

Email: annaalexa@ya.ru
м. н. c. Лаб. анализа генома

Екатерина Дмитриевна Санина

Институт общей генетики им. Н. И. Вавилова РАН

Email: lady.skeit@yandex.ru
н. c. Лаб. анализа генома

Вячеслав Иванович Ширманов

Российский институт дружбы народов

Email: 777doktor@bk.ru
ассистент кафедры. Каф. туберкулеза

Владимир Анатольевич Кошечкин

Российский институт дружбы народов

Email: asept@starnet.ru
заведующий кафедрой. Каф. туберкулеза

Олег Павлович Балановский

Институт общей генетики им. Н. И. Вавилова РАН

Email: balanovsky@inbox.ru
зав. лаб. Лаб. геномной географии

Николай Казимирович Янковский

Институт общей генетики им. Н. И. Вавилова РАН

Email: yankovsky@vigg.ru
зав. лаб. Лаб. анализа генома

Светлана Александровна Боринская

Институт общей генетики им. Н. И. Вавилова РАН

Email: borinskaya@vigg.ru
и. о. г. н. с. Лаб. анализа генома

Список литературы

  1. Степанов В. А., Балановский О. П., Мельников А. В. с соавт. 2011. Характеристика популяций Российской Федерации по панели пятнадцати локусов, используемых для ДНК-идентификации и в судебно-медицинской экспертизе. Acta Naturаe. Т. 3. № 2 (9): С. 59-71.
  2. Научная электронная библиотека elibrary.ru. Доступ 25.10.2013. URL: www.elibrary.ru.
  3. Albani D., Vittori A., Batelli S. et al., (2009) Serotonin transporter gene polymorphic element 5-HTTLPR increases the risk of sporadic Parkinson's disease in Italy. Eur Neurol. V. 62(2): P. 120-123.
  4. Al-Eitan L. N., Jaradat S. A., Qin W. et al., 2012. Characterization of serotonin transporter gene (SLC6A4) polymorphisms and its association with drug dependence in a Jordanian Arab population. Toxicol Ind Health. (Published online before print).
  5. ALFRED (Allele Frequency Database). Cited 25.10.2013. URL: http://alfred.med.yale.edu/alfred/.
  6. Baganz N. L., Blakely R. D. (2013) A dialogue between the immune system and brain, spoken in the language of serotonin. ACS Chem Neurosci. V. 4(1): P. 48-63.
  7. Bisso-Machado R., Ramallo V., Tarazona-Santos E. et al. (2013) 5-HTTLPR genetic diversity and mode of subsistence in Native Americans. Am J Phys Anthropol. V. 151(3): P. 492-494.
  8. Bonvicini C., Minelli A., Scassellati C. et al. (2010) Serotonin transporter gene polymorphisms and treatment-resistant depression. Prog Neuropsychopharmacol Biol Psychiatry. V. 34 (6): P. 934-939.
  9. Butovskaya M. L., Vasilyev V. A., Lazebny O. E. et al. (2012) Aggression, Digit Ratio, and Variation in the Androgen Receptor, Serotonin Transporter, and Dopamine D4 Receptor Genes in African Foragers: The Hadza. Behav. Genet. V. 42(4): P. 647-662.
  10. Caspi A., Sugden K., Moffitt T. E. et al. (2003) Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene.//Science. V. 301: P. 386-389.
  11. Caspi A., Hariri A. R., Holmes A. et al. (2010) Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits. Am J Psychiatry. V. 167(5): P. 509-527.
  12. Cervilla J. A., Rivera M., Molina E. et al. (2006) PREDICT Study Core Group. The 5-HTTLPR s/s genotype at the serotonin transporter gene (SLC6A4) increases the risk for depression in a large cohort of priy care attendees. P. the PREDICT-gene study. Am J Med Genet B Neuropsychiatr Genet. V. 141B(8): P. 912-917.
  13. Chabane N., Millet B., Delorme R. et al. (2004) Lack of evidence for association between serotonin transporter gene (5-HTTLPR) and obsessive-compulsive disorder by case control and family association study in humans. Neurosci Lett. V. 363(2): P. 154-156.
  14. Chiao J. Y., Blizinsky K. D. (2010) Culture-gene coevolution of individualism-collectivism and the serotonin transporter gene. Proc Biol Sci. V. 277(1681): P. 529-537.
  15. Chong S. A., Lee W. L., Tan C. H.et al. (2000) Attempted suicide and polymorphism of the serotonin transporter gene in Chinese patients with schizophrenia. Psychiatry Res. V. 97(2-3): P. 101-106.
  16. Database for autosomal short tandem repeats. Cited 25.10.2013. URL: http://allstr.de.
  17. De Neve J. E., Christakis N. A., Fowler J. H., Frey B. S. (2012) Genes, Economics, and Happiness. J Neurosci Psychol Econ. V. 5(4): P. 193-211.
  18. Eisenberg D. T., Hayes M. G. (2011) Testing the null hypothesis: comments on “Culture-gene coevolution of individualism-collectivism and the serotonin transporter gene”. Proceedings of the Royal Society B: Biological Sciences. 278(1704): P. 329-332.
  19. Elston R. C., Forthofer R. (1977) Testing for Hardy-Weinberg equilibrium in small samples. Biometrics. V. 33: P. 536-542.
  20. Esau L., Kaur M., Adonis L., Arieff Z. (2008) The 5-HTTLPR polymorphism in South African healthy populations: a global comparison. J Neural Transm. V. 115(5): P. 755-760.
  21. Farjadian S., Fakhraei B., Moeini M. et al. (2013) Serotonin transporter gene polymorphisms in Southwestern Iranian patients with irritable bowel syndrome. Arab J Gastroenterol. V. 14(2): P. 59-62.
  22. Grabe H. J., Spitzer C., Schwahn C. et al. (2009) Serotonin transporter gene (SLC6A4) promoter polymorphisms and the susceptibility to posttraumatic stress disorder in the general population. Am J Psychiatry. V. 166(8): P. 926-933.
  23. Guhathakurta S., Ghosh S., Sinha S. et al. (2006) Serotonin transporter promoter variants. P. Analysis in Indian autistic and control population. Brain Res. V. 1092(1): P. 28-35.
  24. Gustavsson J. P., Nöthen M. M., Jönsson E. G. et al. (1999) No association between serotonin transporter gene polymorphisms and personality traits. Am J Med Genet. V. 88(4): P. 430-436.
  25. Hancock A. M., Witonsky D. B., Ehler E. et al. (2010) Colloquium paper: human adaptations to diet, subsistence, and ecoregion are due to subtle shifts in allele frequency. Proc. Natl. Acad. Sci. USA. V. 107(2): P. 8924-3890.
  26. Heils A., Teufel A., Petri S., Stober G. Et al. (1996) Allelic variation of human serotonin transporter gene expression. J. Neurochem. V. 66: P. 2621-2624.
  27. Hofstede G. (2001) Culture’s consequences: comparing values, behaviors, institutions and organizations across nations. (2nd ed.). Thousand Oaks, CA: SAGE Publications.
  28. Jacob C. P., Strobel A., Hohenberger K. et al. (2004) Association between allelic variation of serotonin transporter function and neuroticism in anxious cluster C personality disorders. Am J Psychiatry. V. 161(3): P. 569-572.
  29. Karg K., Burmeister M., Shedden K., Sen S. 2011. The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation. Arch Gen Psychiatry. V. 68(5): P. 444-454.
  30. Katsuragi S., Kunugi H., Sano A. et al. (1999) Association between serotonin transporter gene polymorphism and anxiety-related traits. Biol Psychiatry. V. 45: P. 368-370.
  31. Kenna G. A., Roder-Hanna N., Leggio L. et al. (2012) Association of the 5-HTT gene-linked promoter region (5-HTTLPR) polymorphism with psychiatric disorders: review of psychopathology and pharmacotherapy. Pharmgenomics Pers Med. V. 5: P. 19-35.
  32. Kim S. J., Kang J. I., Namkoong K., Song D. H. (2011)The effects of serotonin transporter promoter and monoamine oxidase A gene polymorphisms on trait emotional intelligence. Neuropsychobiology. V. 64(4): P. 224-230.
  33. Koenen K. C., Aiello A. E., Bakshis E. et al. (2009) Modification of the Association Between Serotonin Transporter Genotype and Risk of Posttraumatic Stress Disorder in Adults by County-Level Social Environment. American Journal of Epidemiology. V. 169(6): P. 704-711.
  34. Landaas E. T., Johansson S., Jacobsen K. K. et al. (2010) An international multicenter association study of the serotonin transporter gene in persistent ADHD. Genes Brain Behav. V. 9(5): P. 449-458.
  35. Lazary J., Lazary A., Gonda X. et al. (2008) New Evidence for the Association of the Serotonin Transporter Gene (SLC6A4) Haplotypes, Threatening Life Events, and Depressive Phenotype. Biol Psychiatry. V. 64: P. 498-504.
  36. Lesch K.-P., Bengel D., Heils A. et al. (1996) Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science. V. 274: P. 1527-1530.
  37. Li J., Wang Y., Zhou R. et al., 2007 Association between polymorphisms in serotonin transporter gene and attention deficit hyperactivity disorder in Chinese Han subjects. Am J Med Genet B Neuropsychiatr Genet. V. 144B(1). P. 14-19.
  38. Long H., Liu B., Hou B. et al. (2013) The long rather than the short allele of 5-HTTLPR predisposes Han Chinese to anxiety and reduced connectivity between prefrontal cortex and amygdala. Neurosci Bull. V. 29(1): P. 4-15.
  39. Lotrich F. E., Pollock B. G., Ferrell R. E. (2003) Serotonin transporter promoter polymorphism in African Americans: allele frequencies and implications for treatment. Am J Pharmacogenomics. V. 3(2): P.145-147.
  40. Manor I., Eisenberg J., Tyano S. et al. Family-based association study of the serotonin transporter promoter region polymorphism (5-HTTLPR) in attention deficit hyperactivity disorder. Am J Med Genet. V. 105(1). P. 91-95.
  41. Maron E., Tammiste A., Kallassalu K. et al. (2009) Serotonin transporter promoter region polymorphisms do not influence treatment response to escitalopram in patients with major depression. Eur Neuropsychopharmacol. V. 19(6): P. 451-456.
  42. Martaskova D., Slachtová L., Kemlink D. et al. (2009) Polymorphisms in serotonin-related genes in anorexia nervosa. The first study in Czech population and metaanalyses with previously performed studies. Folia Biologica. V. 55: P. 192-197.
  43. Matsunaga М., Isowa T., Yamakawa K., Ohira H. (2013) Association between the serotonin transporter polymorphism (5HTTLPR) and subjective happiness level in Japanese adults. Psychology of Well-Being: Theory, Research and Practice V. 3: P. 5.
  44. Middeldorp C. M., de Geus E. J., Beem A. L.et al. (2007) Family based association analyses between the serotonin transporter gene polymorphism (5-HTTLPR) and neuroticism, anxiety and depression. Behav Genet. V. 37(2): P. 294-301.
  45. Miu A. C., Crişan L. G., Chiş A. et al. (2012) Somatic markers mediate the effect of serotonin transporter gene polymorphisms on Iowa Gambling Task. Genes, Brains, Behavior. V. 11(4): P. 398-403
  46. Mohamed Saini S., Nik Jaafar N. R., Sidi H. et al. (2013) Serotonin Transporter Gene Polymorphism and its association with bipolar disorder across different ethnic groups in Malaysia. Compr Psychiatry. pii: S0010-440X (12)00261-1.
  47. Munafò M. R., Durrant C., Lewis G., Flint J. (2009) Gene X environment interactions at the serotonin transporter locus. Biol Psychiatry. V. 65(3): P. 211-219.
  48. Murakami F., Shimomura T., Kotani K. et al. (1999) Anxiety traits associated with a polymorphism in the serotonin transporter gene regulatory region in the Japanese. J Hum Genet. V. 44(1): P. 15-17.
  49. Murdoch J. D., Speed W. C., Pakstis A. J. et al. (2013) Worldwide population variation and haplotype analysis at the serotonin transporter gene SLC6A4 and implications for association studies. Biol Psychiatry. V. 74(12): P. 879-889.
  50. Nasserddine S., Hamzi K., Diakite N. et al. (2012) Distribution of 5-HTTLPR Serotonin Transporter Polymorphism in Moroccan Population. Int J LifeSci & Pharm Res. Vol. 1: P. 278-281.
  51. Noskova T., Pivac N., Nedic G. et al. (2008) Ethnic differences in the serotonin transporter polymorphism (5-HTTLPR) in several European populations. Prog Neuropsychopharmacol Biol Psychiatry. V. 32(7). P. 1735-1739.
  52. Noskova T., Pivac N., Nedic G., Kazantseva A. (2008) Ethnic differences in the serotonin transporter polymorphism (5-HTTLPR) in several European populations. Prog. Neuro-Psychopharmacol. Biol. Psychiatry. V. 32: P. 1735-1739.
  53. Novembre J., Johnson T., Bryc K. et al. (2008) Genes mirror geography within Europe. Nature V. 456(7218): P. 98-101.
  54. PubMed. Cited 25.10.2013. URL: http://www.ncbi.nlm.nih.gov/pubmed/.
  55. Pungercic G., Videtic A., Pestotnik A. et al. (2006) Serotonin transporter gene promoter (5-HTTLPR) and intron 2 (VNTR) polymorphisms: a study on Slovenian population of suicide victims. Psychiatr Genet. V. 16(5): P. 187-91.
  56. Ramamoorthy S., Bauman A. L., Moore K. R. et al. (1993) Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization. Proc. Nat. Acad. Sci. V. 90(6): P. 2542-2546.
  57. Risch N., Herrell R., Lehner T. et al. (2009) Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis. JAMA. V. 301(23): P. 2462-2471.
  58. Rosenberg N. A., Mahajan S., Ramachandran S. et al. (2005) Clines, clusters, and the effect of study design on the inference of human population structure. PLoS Genet. V. 1: P. e70.
  59. Saiz P. A., Garcia-Portilla M. P., Arango C. (2008) Association study between obsessive-compulsive disorder and serotonergic candidate genes. Prog Neuropsychopharmacol Biol Psychiatry. V. 32(3): P. 765-770.
  60. Sanders-Bush E., Mayer S. E. (2006) 5-Hydroxytryptamine (serotonin) receptor agonists and antagonists. In: Brunton L. L., Lazo J. S., Parker K. L., editors. The Pharmacological Basis of Therapeutics. Goodman &, Gilman's McGaw-Hill; P. 297-315.
  61. Schild A. H., Nader I. W., Pietschnig J., Voracek M. (2014) Ethnicity Moderates the Association Between 5-HTTLPR and National Suicide Rates. Arch Suicide Res. V.18 (1): P. 1-13.
  62. Shen Y., Li H., Gu N. et al. (2004) Relationship between suicidal behavior of psychotic inpatients and serotonin transporter gene in Han Chinese. Neurosci Lett. V. 372(1-2): P. 94-98.
  63. Sieminska A., Buczkowski K., Jassem E., Tkacz E. (2008) Lack of association between serotonin transporter gene polymorphism 5-HTTLPR and smoking among Polish population: a case-control study. BMC Med Genet. V. 9: P. 76.
  64. Szekely A., Ronai Z., Nemoda Z. et al. (2004) Human personality dimensions of persistence and harm avoidance associated with DRD4 and 5-HTTLPR polymorphisms. Am J Med Genet. Part B. V. 126B(1): P. 106-110.
  65. Tabagh R., Andres C. R., Védrine S. et. (2010) Study of the serotonin transporter (SLC6A4) and BDNF genes in French patients with non syndromic mental deficiency. BMC Med Genet. V. 11: P. 30.
  66. Tencomnao T., Sritharathikhunb T., Suttiratc S. (2010) Influence of demographic factors and serotonin transporter-linked polymorphic region (5-HTTLPR) variants on major depression in a northeastern Thai population. Asian Biomedicine. V. 4: P. 893-899.
  67. The Distribution of the Human DNA-PCR Polymorphisms. Cited 10.01.2014. URL: http://www.uniduesseldorf.de/WWW/MedFak/Serology/database.html.
  68. The Hofstede Centre. Cited 12.02.2014. URL: http://geert-hofstede.com/.
  69. Tibrewal P., Ku H. B., Shubha G. N. et al. (2010) Association of serotonin transporter gene polymorphisms with obsessive-compulsive disorder (OCD) in a south Indian population. Indian J Med Res. V. 132: P. 690-695.
  70. Tsai S. J., Hong C. J., Cheng C. Y. (2002) Serotonin transporter genetic polymorphisms and harm avoidance in the Chinese. Psychiatr Genet. V. 12: P. 165-168.
  71. Way B. M., Lieberman M. D. (2010) Is there a genetic contribution to cultural differences? Collectivism, individualism and genetic markers of social sensitivity. Soc Cogn Affect Neurosci. V. 5(2-3): P. 203-211.
  72. Wichers M., Kenis G., Jacobs N. (2008) The BDNF Val (66)Met x 5-HTTLPR x child adversity interaction and depressive symptoms: An attempt at replication. Am J Med Genett Part B. 147B. P. 120-123.
  73. Willeit M, Praschak-Rieder N, Neumeister A. et al. (2003) A polymorphism (5-HTTLPR) in the serotonin transporter promoter gene is associated with DSM-IV depression subtypes in seasonal affective disorder. Mol Psychiatry. V. 8(11): P. 942-946.
  74. Willis-Owen S. A., Turri M. G., Munafò M. R. et al. (2005) Surtees P. G., Wainwright N. W., Brixey R. D., Flint J. The serotonin transporter length polymorphism, neuroticism, and depression: a comprehensive assessment of association. Biol Psychiatry. V. 58(6): P. 451-456.

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© Гуреев А.С., Ким А.А., Санина Е.Д., Ширманов В.И., Кошечкин В.А., Балановский О.П., Янковский Н.К., Боринская С.А., 2014

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