Clinical case of Guillain-Barré syndrome associated with COVID-19
- Authors: Shirshova E.V.1, Knaub V.V.2, Baklaushev V.P.3
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Affiliations:
- Federal Research and Clinical Center of Specialized Medical Care and Medical Technologies
- Federal Clinical and Research Center for Specialized Medical Care and Medical Technologies of the Federal Medical Biological Agency
- Federal Research and Clinical Center of Specialized Medical Care and Medical Technologies FMBA of Russia
- Issue: Vol 12, No 2 (2021)
- Pages: 110-118
- Section: Case reports
- URL: https://journals.rcsi.science/clinpractice/article/view/72264
- DOI: https://doi.org/10.17816/clinpract72264
- ID: 72264
Cite item
Abstract
Background: The coronavirus infection caused by SARS-Cov-2 is characterized by a damage to many organs and systems of the human body. To date, convincing information has been obtained about the involvement of various parts of the nervous system in the pathological process in patients with COVID-19. Among the most frequently described impairments, there are disorders of smell and taste, common disorders of the central nervous system, characterized by general cerebral symptoms, such as headache, asthenization, psychopathological disorders. One of the rare and severe forms of the peripheral nervous system damage in COVID-19 is Guillain-Barre syndrome (GBS), characterized by acute post-infectious inflammatory polyneuropathy with an autoimmune etiology. Clinical case description. We present a clinical case of GBS associated with COVID-19. The disease debuted as a peripheral tetraparesis with a progredient course of up to 21 days. Systemic administration of immunoglobulin stopped the disease progression. The association of GBS with COVID-19 was clarified a month after the disease onset, when bilateral polysegmental pneumonia was diagnosed, and a high level of IgG to the S-protein of SARS-CoV-2 was found, 3 times higher than the level of IgM, which indicated the duration of the disease was not less than three weeks. Conclusion: The GBS development upon infection with SARS-CoV-2 may precede the lung damage. The debut of GBS during the COVID-19 pandemic requires the exclusion of the SARS-CoV-2 etiological role in each case.
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##article.viewOnOriginalSite##About the authors
Elena V. Shirshova
Federal Research and Clinical Center of Specialized Medical Care and Medical Technologies
Author for correspondence.
Email: shirshova.ev@fnkc-fmba.ru
ORCID iD: 0000-0001-9193-0534
SPIN-code: 7491-0434
MD, Dr. Sci. (Med.)
Russian Federation, 28, Orekhovy blvd, Moscow, 115682Vladimir V. Knaub
Federal Clinical and Research Center for Specialized Medical Care and Medical Technologies of the Federal Medical Biological Agency
Email: knaub.vladimir.v@gmail.com
ORCID iD: 0000-0002-1688-3923
Neurologist
Russian Federation, 28, Orekhovy blvd, Moscow, 115682Vladimir P. Baklaushev
Federal Research and Clinical Center of Specialized Medical Care and Medical Technologies FMBA of Russia
Email: baklaushev.vp@fnkc-fmba.ru
ORCID iD: 0000-0003-1039-4245
SPIN-code: 3968-2971
Dr. Sci. (Med.)
Russian Federation, 28 Orekhovy boulevard, Moscow, 115682References
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