Additional diagnostic capabilities in the practice of a PAP-test using liquid-based cytology
- Authors: Aksamentov A.K.1, Melnikova N.V.1,2, Kolyshkina N.A.1, Kucherova O.N.3, Baklaushev V.P.1
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Affiliations:
- Federal Research and Clinical Center of Specialized Medical Care and Medical Technologies FMBA of Russia
- Russian Scientific Center of Roentgenoradiology
- City Clinical Hospital named after V.V. Vinogradov of the Department of Health of the city of Moscow
- Issue: Vol 12, No 1 (2021)
- Pages: 82-89
- Section: Reviews
- URL: https://journals.rcsi.science/clinpractice/article/view/64982
- DOI: https://doi.org/10.17816/clinpract64982
- ID: 64982
Cite item
Abstract
The role of oncogenic strains of human papillomavirus in the development of cervical cancer is currently not in doubt. In cervical cancer screening, a co-testing strategy is used, in which cytology and HPV testing are performed. When performing a cytological examination by liquid-based cytology, it is possible to conduct additional diagnostic studies that can be used to more effectively sort patients in order to optimize the volume of diagnostic and therapeutic measures. The article highlights the possibilities of diagnostic tests based on the assessment of microRNA and mRNA expression, as well as tests based on the analysis of DNA methylation from the cytological material. The introduction of new molecular genetic predictors of the cervical cancer development into clinical practice can increase the effectiveness of currently used screening programs.
Keywords
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##article.viewOnOriginalSite##About the authors
Artem K. Aksamentov
Federal Research and Clinical Center of Specialized Medical Care and Medical Technologies FMBA of Russia
Author for correspondence.
Email: temaaxe@rambler.ru
ORCID iD: 0000-0002-7980-2537
SPIN-code: 7861-6556
MD
Russian Federation, 28 Orekhovy boulevard, Moscow, 115682Nadezhda V. Melnikova
Federal Research and Clinical Center of Specialized Medical Care and Medical Technologies FMBA of Russia; Russian Scientific Center of Roentgenoradiology
Email: n_melnikova@list.ru
ORCID iD: 0000-0003-1193-352X
SPIN-code: 5050-8605
Cand. Sci. (Med.)
Russian Federation, 28 Orekhovy boulevard, Moscow, 115682; MoscowNadezhda A. Kolyshkina
Federal Research and Clinical Center of Specialized Medical Care and Medical Technologies FMBA of Russia
Email: baklab_83@mail.ru
ORCID iD: 0000-0003-4486-5412
MD
Russian Federation, 28 Orekhovy boulevard, Moscow, 115682Olga N. Kucherova
City Clinical Hospital named after V.V. Vinogradov of the Department of Health of the city of Moscow
Email: ola-kucherova@mail.ru
ORCID iD: 0000-0003-3773-9629
Cand. Sci. (Med)
Russian Federation, MoscowVladimir P. Baklaushev
Federal Research and Clinical Center of Specialized Medical Care and Medical Technologies FMBA of Russia
Email: baklaushev.vp@fnkc-fmba.ru
ORCID iD: 0000-0003-1039-4245
SPIN-code: 3968-2971
Dr. Sci. (Med.)
Russian Federation, 28 Orekhovy boulevard, Moscow, 115682References
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