The use of quadrotherapy of chronic heart failure in cancer patients (case series)
- Authors: Peresada A.K.1, Dupik N.V.1, Dundua D.P.1, Kedrova A.G.1, Korolev S.V.1, Chaikin R.S.1
-
Affiliations:
- Federal Scientific and Clinical Center for Specialized Medical Assistance and Medical Technologies
- Issue: Vol 14, No 2 (2023)
- Pages: 96-104
- Section: Case reports
- URL: https://journals.rcsi.science/clinpractice/article/view/142798
- DOI: https://doi.org/10.17816/clinpract202813
- ID: 142798
Cite item
Abstract
Background: Chronic heart failure (CHF) for a patient with cancer is complex, as it complicates antitumor treatment. In some cases, severe CHF is a contraindication to the chemotherapy or surgical treatment. Despite significant progress in CHF treatment, some groups of drugs, particularly mineralocorticoid receptor inhibitors, angiotensin receptor-neprilysin inhibitors, and sodium-glucose co-transporter type 2 inhibitors, have not been studied related to cancer patients.
Clinical case description: In this report, we introduce two clinical cases in which, because of the invaluable contribution of the cardio-oncological team, we have managed to solve complex problems of treating patients with CHF and cancer. In patient 1 with severe CHF, it was possible to achieve regression of systolic dysfunction, despite the progression of bladder cancer T4N1M0. In patient 2 with severe ischemic cardiopathy and CHF, owing to the timely administration of quadruple therapy, we managed to significantly improve the cardiac status and increase the LV EF that the patient underwent gastrectomy and cholecystectomy for cancer of the cardiac part of the stomach cT2N0M0 without complications.
Conclusion: The above clinical cases demonstrate the possibilities of a team, multidisciplinary approach in the treatment of complex category of patients with CHF and active oncological disease. Modern therapy of cancer patients with severe heart failure allows successful antitumor treatment.
Full Text
##article.viewOnOriginalSite##About the authors
Anton K. Peresada
Federal Scientific and Clinical Center for Specialized Medical Assistance and Medical Technologies
Author for correspondence.
Email: tony.peresada@yandex.ru
ORCID iD: 0000-0001-7128-0183
SPIN-code: 2518-6553
Russian Federation, Moscow
Nikolay V. Dupik
Federal Scientific and Clinical Center for Specialized Medical Assistance and Medical Technologies
Email: dnv-74@yandex.ru
ORCID iD: 0000-0002-3597-4265
Russian Federation, Moscow
David P. Dundua
Federal Scientific and Clinical Center for Specialized Medical Assistance and Medical Technologies
Email: david.doundoua@gmail.com
ORCID iD: 0000-0001-7345-0385
Dr. Sci. (Med.), Professor
Russian Federation, MoscowAnna G. Kedrova
Federal Scientific and Clinical Center for Specialized Medical Assistance and Medical Technologies
Email: kedrova.anna@gmail.com
ORCID iD: 0000-0003-1031-9376
SPIN-code: 3184-9760
Dr. Sci. (Med.), Professor
Russian Federation, MoscowSergey V. Korolev
Federal Scientific and Clinical Center for Specialized Medical Assistance and Medical Technologies
Email: sergejkorolev@yandex.ru
ORCID iD: 0000-0001-5513-2332
SPIN-code: 4545-3450
MD, PhD
Russian Federation, MoscowRoman S. Chaikin
Federal Scientific and Clinical Center for Specialized Medical Assistance and Medical Technologies
Email: chaikin.transpl@gmail.com
ORCID iD: 0000-0002-8667-0392
Russian Federation, Moscow
References
- Hasin T., Gerber Y., McNallan S.M., et al. Patients with heart failure has an increased risk of incident cancer. J Am Coll Cardiol.2013;62(10):881–886. doi: 10.1016/j.jacc.2013.04.088
- Lyon A.R., López-Fernández T., Couch L.S., et al. ESC Guidelines on cardio-oncology developed in collaboration with the European Hematology Association (EHA), the European Society for Therapeutic Radiology and Oncology (ESTRO) and the International Cardio-Oncology Society (IC-OS). Eur Heart J. 2022. doi: 10.1093/eurheartj/ehac244
- Chen M.H., Colan S.D., Diller L. Cardiovascular disease: Cause of morbidity and mortality in adult survivors of childhood cancers. Circ Res. 2011;108(5):619–628. doi: 10.1161/CIRCRESAHA.110.224519
- Seicean A., Alan N. Cardioprotective effect of β-adrenoceptor blockade in patients with breast cancer undergoing chemotherapy: Follow-up study of heart failure. Circ Heart Fail. 2013;6(3): 420–426. doi: 10.1161/CIRCHEARTFAILURE.112.000055
- Livi L., Barletta G., Martella F., et al. Cardioprotectivestrategy for patients with nonmetastatic breast cancer who are receiving an anthracycline-based chemotherapy: A randomized clinical trial. JAMA Oncol. 2021;7(10):1544–1549. doi: 10.1001/jamaoncol.2021.3395
- Виценя М.В., Потехина А.В., Гаврюшина С.В., и др. Профилактика и лечение дисфункции левого желудочка и сердечной недостаточности, связанных с противоопухолевой терапией: возможности и перспективы // Эффективная фармакотерапия. 2020. Т. 16, № 18. С. 108–120. [Vitsenya M.V., Potekhina A.V., Gavryushina S.V., et al. Prevention and treatment of left ventricular dysfunction and heart failure associated with antitumor therapy: Opportunities and prospects. Effect Pharmacother. 2020;16(18):108–120. (In Russ).] doi: 10.33978/2307-3586-2020-16-18-108-120
- Vitsenya M.V., Potekhina A.V., Stukalova O.V. Onset of heart failure after anthracycline therapy in the adult: Treatment and expectations for recovery. In: R.M. Steingart, J.E. Liu, eds. Atlas of imaging in cardio-oncology. Springer, Cham; 2021. doi: 10.1007/978-3-030-70998-3_27
- Seicean S., Seicean A., Plana J.C., et al. Effect of statin therapy on the risk for incident heart failure in patients with breast cancer receiving anthracycline chemotherapy: An observational clinical cohort study. J Am Coll Cardiol. 2012;60(23):2384–2390. doi: 10.1016/j.jacc.2012.07.067
- Zelniker T.A., Braunwald E. Mechanisms of cardiorenal effects of sodium-glucose cotransporter 2 inhibitors: JACC state-of-the-art review. J Am Coll Cardiol. 2020;75(4):422–434. doi: 10.1016/j.jacc.2019.11.031
- Verma S., Rawat S., Ho K.L., et al. Empagliflozinincreases cardiac energy production in diabetes: Novel translational insights into the heart failure benefits of SGLT2 Inhibitors. JACC Basic Transl Sci. 2018;3(5):575–587. doi: 10.1016/j.jacbts.2018.07.006
- Чазова И.Е., Шестакова М.В., Жернакова Ю.В., и др. Евразийские рекомендации по профилактике и лечению сердечно-сосудистых заболеваний у больных с диабетом и предиабетом // Евразийский кардиологический журнал. 2021. № 2. С. 6–61. [Chazova I.E., Shestakova M.V., Zhernakova Yu.V.,etal. Eurasian Association of Cardiology (EAC) guidelines for the prevention and treatment of cardiovascular diseases in patients with diabetes and prediabetes. EurHeart J. 2021;(2):6–61. (In Russ).] doi: 10.38109/2225-1685-2021-2-6-61
- Zannad F., Ferreira J.P., Pocock. S.J., et al. SGLT2 inhibitors in patients with heart failure with reduced ejection fraction: A meta-analysis of the EMPEROR-Reduced and DAPA-HF trials. Lancet. 2020;396(10254):819–829. doi: 10.1016/S0140-6736(20)31824-9
- Anker S.D., Butler J., Filippatos G., et al. Empagliflozin in heart failure with a preserved ejection fraction. N Engl J Med. 2021;385(16):1451–1461. doi: 10.1056/NEJMoa2107038
- Ponikowski P., Voors A.A., Anker S.D., et al. ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J. 2016;18(8):891–975. doi: 10.1002/ejhf.592
- McDonagh T.A., Metra M., Adamo M., et al. ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J. 2021;42(36):3599–3726. doi: 10.1093/eurheartj/ehab368
- Gongora C.A., Drobni Z.D., Silva T.Q.,et al. Sodium-glucose co-transporter-2 inhibitors and cardiac outcomes among patients treated with anthracyclines. JACC Heart Fail. 2022;10(8): 559–567. doi: 10.1016/j.jchf.2022.03.006
- Васюк Ю.А., Гендлин Г.Е. Согласованное мнение российских экспертов по профилактике, диагностике и лечению сердечно-сосудистой токсичности противоопухолевой терапии // Российский кардиологический журнал.2021. Т. 26, № 9. С. 4703. Vasyuk Yu.A., Gendlin G.E. The agreed opinion of Russian experts on the prevention, diagnosis and treatment of cardiovascular toxicity of antitumor therapy. Russ J Cardiol. 2021;26(9):4703. (In Russ).] doi: 10.15829/1560-4071-2021-4703
- Akpek M., Ozdogru I., Sahin O., et al. Protective effects of spironolactone against anthracyclin-induced cardiomyopathy. Eur J Heart Fail. 2015;17:81–89. doi: 10.1002/ejhf.196
- McMurray J.J., Packer M., Desai A.S., et al. PARADIGM-HF Investigators and Committees. Angiotensin-neprilysin inhibition versus enalapril in heart failure. N Engl J Med. 2014;37: 993–1004. doi: 10.1056/NEJMoa1409077