Email this article Pertussis is still not a completely controlled infection
- Authors: Neverov V.A.1, Kirpichnikova G.I.1, Antonov V.M.1, Startseva G.Y.1, Klur M.V.1
-
Affiliations:
- North-Western State Medical University named after I.I. Mechnikov
- Issue: Vol 28, No 3 (2024)
- Pages: 5-15
- Section: Lectures
- URL: https://journals.rcsi.science/RFD/article/view/268239
- DOI: https://doi.org/10.17816/RFD625730
- ID: 268239
Cite item
Open Access
Access granted
Subscription Access
Abstract
The lecture focuses on pertussis, an infection managed by specific preventive measures, which continues to threaten both child and maternal health, as well as overall healthcare system.
Despite high vaccination rates, pertussis remains an “under-controlled” infection and a significant contributor to childhood morbidity and mortality. Moreover, in many countries, the incidence of pertussis is clearly rising among both children and adults, with a notable proportion of cases occurring in vaccinated individuals.
This increase may be associated with changes in the antigenic structure of the pathogen, the limited duration of post-vaccination immunity, reduced vaccination coverage, and the use of more sensitive laboratory diagnostic methods.
The lecture addresses modern aspects of the etiopathogenesis, epidemiology, clinical presentation, diagnosis, treatment, and prevention of pertussis. Given the rising incidence of this infection in Russia and several other countries in 2023, the information presented will be especially valuable for practitioners, particularly family doctors.
Full Text
##article.viewOnOriginalSite##About the authors
Vladimir A. Neverov
North-Western State Medical University named after I.I. Mechnikov
Author for correspondence.
Email: v.neveroff@mail.ru
ORCID iD: 0009-0003-7951-5508
SPIN-code: 1798-2618
MD, Cand. Sci. (Medicine), Associate Professor
Russian Federation, Saint PetersburgGalina I. Kirpichnikova
North-Western State Medical University named after I.I. Mechnikov
Email: sotnik26@bk.ru
ORCID iD: 0009-0004-8767-2332
Cand. Sci. (Biology), Associate Professor
Russian Federation, Saint PetersburgVsevolod M. Antonov
North-Western State Medical University named after I.I. Mechnikov
Email: Vsevolod.Antonov@szgmu.ru
ORCID iD: 0009-0002-3172-7926
SPIN-code: 9925-2139
Cand. Sci. (Medicine), Associate Professor
Russian Federation, Saint PetersburgGalina Yu. Startseva
North-Western State Medical University named after I.I. Mechnikov
Email: star661@rambler.ru
ORCID iD: 0000-0002-3660-2666
SPIN-code: 8392-2950
MD, Cand. Sci. (Medicine), Associate Professor
Russian Federation, Saint PetersburgMargarita V. Klur
North-Western State Medical University named after I.I. Mechnikov
Email: rita-med@mail.ru
ORCID iD: 0009-0006-6222-2452
MD, Cand. Sci. (Medicine), Associate Professor
Russian Federation, Saint PetersburgReferences
- Tatochenko VK. Pertussis — infection not under complete control. Current Pediatrics (Moscow). 2014;13(2):78–82. EDN: SBUALT doi: 10.15690/vsp.v13i2.975
- Pertussis: Standards for surveillance of vaccine-preventable diseases. WHO. September 4, 2018 [Internet]. Available from: https://www.who.int/ru/publications/m/item/vaccine-preventable-diseases-surveillance-standards-pertussis. Accessed: 09 Jan 2024.
- Report “Socio-economic situation in Russia” 2023 [Internet]. Rosstat. Ministry of Economic Development of Russia. Available from: https://rosstat.gov.ru/compendium/document/50801. Accessed: 09 Jan 2024. (In Russ.)
- On the state of sanitary and epidemiological well-being of the population in the Russian Federation in 2022: State report [Internet]. Federal Service for Supervision of Consumer Rights Protection and Human Welfare. Moscow; 2023. 370 p. Available from: https://www.rospotrebnadzor.ru/upload/iblock/b50/t4kqksh4b12a2iwjnha29922vu7naki5/GD-SEB.pdf. Accessed: 09 Jan 2024. (In Russ.)
- Babachenko IV, Nesterova YuV, Chernyshova YuYu, et al. Clinical-epidemiological aspects of whooping cough in children in conditions of mass vaccinoprophylactics. Journal of Infectology. 2019;11(2):88–96. EDN: BKEKZC doi: 10.22625/2072-6732-2019-11-2-88-96
- Nesterova YuV, Medkova AYu, Babachenko IV, et al. Clinical-diagnostic value of bordetella pertussis geneticmarkers in contact persons in familial foci. Journal of Infectology. 2019;11(1):17–24. EDN: UBTKHK doi: 10.22625/2072-6732-2019-11-1-17-24
- Bisgard KM, Pascual FB, Ehresmann KR, et al. Infant pertussis: who was the source? Pediatr Infect Dis J. 2004;23:985–989. doi: 10.1097/01.inf.0000145263.37198.2b
- Lobzin YV, Bakhareva NV. Retrospective Study of the clinical epidemiological characteristics of pertussis in infants prior to their first vaccination in the Russian Federation. Infect Dis Ther. 2015;4(1):113–123. doi: 10.1007/s40121-015-0059-9
- Liko J, Steve G, Robison BS, et al. Priming with whole-cell versus acellular pertussis vaccine. N Engl J Med. 2013;368(6):581–582. doi: 10.1056/NEJMc1212006
- Cherry JD. Why do pertussis vaccines fail? Pediatrics. 2012;129:968–970. doi: 10.1542/peds.2011-2594
- Bortolussi R, Miller B, Ledwith M, et al. Clinical course of pertussis in immunized children. Pediatr Infect Dis J. 1995;14:870–874. doi: 10.1097/00006454-199510000-00010
- Sizemov AN, Komeleva EV. Whooping cough: clinic, diagnostics, treatment. Lechaschi Vrach. 2005;7:82–87. (In Russ.)
- Babachenko IV, Kharit SM, Kurova NN, Tseneva GYa. Cough in children. Moscow: Commentary; 2014. 176 p. (In Russ.) EDN: VZMRBN
- Popova OP, Gorelov AV. Modern aspects of whooping cough in children. Moscow: GEOTAR-Media; 2017. 192 p. (In Russ.) EDN: XUXBDT
- Mazurova IK, Borisova OYu, Petrova MS. Bordetella is the causative agent of whooping cough. In: Labinskaya AS, Kostyukova NN, Ivanova SM, editors. Guide to medical microbiology. Private medical microbiology and etiological diagnosis of infections. Moscow: Binom; 2010. P. 645–668. (In Russ.)
- Kilgore PE, Salim AM, Zervous MJ, Schmitt H-J. Pertussis: Microbiology, disease, treatment, and prevention. Clin Microbiol Rev. 2016;29(3):449–486. doi: 10.1128/cmr.00083-15
- Clinical recommendations “Whooping cough in children 2019” [Internet]. Available from: http://niidi.ru/dotAsset/81b423f4-54db-46be-ab61-eba09a97e09f.pdf. Accessed: 09 Jan 2024. (In Russ.)
- Waters V, Halperin SA. Bordetella pertussis. In: Bennett JE, Dolin R, Blaser MJ, editors. Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases. 8th ed. Philadelphia: Elsevier Health Sciences; 2015. P. 2619–2628.
- Guidelines MUK 4.2.3701-21 “Laboratory diagnosis of whooping cough and diseases caused by other bordetella” [Internet]. Available from: https://base.garant.ru/403357325/. Accessed: 09 Jan 2024. (In Russ.)
- Svetlichnaya SV, Elagina LA, Popovich LD. Evaluation of the economic efficacy of vaccination against pertussis based on real-world data. Real-World Data and Evidence. 2023;3(1):9–19. EDN: GYOCBZ doi: 10.37489/2782-3784-myrwd-27
- Stepenko AV, Mindlina AYa. Risk management for the development of the epidemic process of whooping cough: missed opportunities and new prospects. Medical almanac. 2017;(4(49)):83–86. (In Russ.)
- Wang K, Fry NK, Campbell H, et al. Whooping cough in school age children presenting with persistent cough in UK primary care after introduction of the preschool pertussis booster vaccination: prospective cohort study. BMJ. 2014;348:g3668. doi: 10.1136/bmj.g3668
Supplementary files
