Steroid hormones and their metabolites in water of centralized drinking water supply systems as ecopolutants

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Information about the presence of drugs and their metabolites in the water of centralized drinking water supply systems is presented; the main groups of drugs found in purified drinking water of large cities are given. The main groups of drugs found in a centralized drinking water supply system include antidepressants (amitriptyllin), antibacterial drugs of various groups (amoxicillin, ciprofloxacin, tetracycline, azithromycin), narcotic analgesics (cocaine, morphine, their derivatives), psychoactive stimulants, benzodiazepines, hormones (estrogen and its metabolites estrone and estriol).

A high level of potential risk to public health is marked due to the presence of steroid hormones and their active metabolites in drinking water. The concept of endocrine dysregulating complexes is formulated. Such complexes can be of a different nature of origin, but all of them affect receptors for estrogen and progesterone. It leads to abnormalities of hormonal regulation, affects endogenous synthesis, transport and secretory function.

From the standpoint of ecotoxicology, further ways of working out the problem of the presence of steroid hormones in drinking water are proposed: the development of theoretical approaches to substantiating hygienic standards concerning the monitoring of these compounds in the water of centralized drinking water supply systems.

作者简介

Nikolay Vengerovich

State Research Testing Institute of Military Medicine of the Ministry of Defense of the Russian Federation; Saint Petersburg State Chemical and Pharmaceutical University of the Ministry of Health of the Russian Federation

Email: nikolai.vengerovich@pharminnotech.com
ORCID iD: 0000-0003-3219-341X
SPIN 代码: 6690-9649
Scopus 作者 ID: 55639823300
Researcher ID: U-3467-2019

Doctor of Medicine (MD), Deputy Head of the Scientific Department, State Scientific Research Testing Institute of Military Medicine of the Ministry of Defense of the Russian Federation, Professor at the Industrial Ecology Department, Saint Petersburg State Chemical and Pharmaceutical University

俄罗斯联邦, Saint Petersburg; Saint Petersburg

Vladimir Perelygin

Saint Petersburg State Chemical and Pharmaceutical University of the Ministry of Health of the Russian Federation

编辑信件的主要联系方式.
Email: vladimir.pereligin@pharminnotech.com
ORCID iD: 0000-0002-0999-5644
SPIN 代码: 3128-7451
Scopus 作者 ID: 13105602000
Researcher ID: AAV-6556-2020

Doctor of Medicine (MD), Professor, Head of the Industrial Ecology Department

俄罗斯联邦, Saint Petersburg

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此作品已接受知识共享署名-非商业性使用-禁止演绎 4.0国际许可协议的许可。
 


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