电邮这篇文章 Pharmacological potential of ligands to receptors of RF-amide neuropeptide system
- 作者: Yakovlev O.A.1, Vengerovich N.G.1,2, Nikiforov A.S.1, Vakhviyaynen M.S.1
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隶属关系:
- State Scientific Research and Test Institute of Military Medicine, Ministry for Defense of the Russian Federation
- Saint Petersburg State Chemical Pharmaceutical University of the Ministry of Health of the Russian Federation
- 期: 卷 4, 编号 1 (2022)
- 页面: 10-17
- 栏目: Pharmaceutical Sciences
- URL: https://journals.rcsi.science/PharmForm/article/view/108266
- DOI: https://doi.org/10.17816/phf108266
- ID: 108266
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详细
The system of neuropeptides has a significant impact on different functions of the central nervous system, acting as a launching ground for the development of new generation drugs that have a complex therapeutic effect in mood disorders, nociception, reproductive behavior with minimal side effects, which is confirmed by the data of a number of preclinical studies. The review considers a promising neuropeptide system of the RF-amide family, which can become the basis for the development of new drugs, complementing the therapeutic possibilities of physiologically active substances with a more selective effect on certain pathological processes. The main groups of neuropeptides of the RF-system were identified: neuropeptides FF, 26 RF-amides, kisspeptins, prolactin-releasing and gonadotropin-inhibiting peptides. For each of these groups descriptions of biological effects are presented, including antinoceptive action, influence on the regulation of energy homeostasis, influence on reproductive behavior, etc. A number of non-peptide ligands for RF-amide receptors developed and available for research have been identified.
作者简介
Oleg Yakovlev
State Scientific Research and Test Institute of Military Medicine, Ministry for Defense of the Russian Federation
编辑信件的主要联系方式.
Email: gniiivm_15@mil.ru
Researcher at the Research Department
俄罗斯联邦, Санкт-ПетербургNikolai Vengerovich
State Scientific Research and Test Institute of Military Medicine, Ministry for Defense of the Russian Federation;Saint Petersburg State Chemical Pharmaceutical University of the Ministry of Health of the Russian Federation
Email: nikolai.vengerovich@pharminnotech.com
ORCID iD: 0000-0003-3219-341X
SPIN 代码: 6690-9649
Scopus 作者 ID: 55639823300
Researcher ID: U-3467-2019
http://eco.pharminnotech.com/sotrudniki-kafedry/vengerovic-nikolaj-georgievic
Doctor of Medical Science, Deputy Head of Department, Professor at the Industrial Ecology Department
俄罗斯联邦, Санкт-ПетербургAleksandr Nikiforov
State Scientific Research and Test Institute of Military Medicine, Ministry for Defense of the Russian Federation
Email: gniiivm_15@mil.ru
SPIN 代码: 3169-7701
Doctor of Biol. Sciences, Associate Professor, Leading Researcher
俄罗斯联邦, Санкт-ПетербургMaria Vakhviyaynen
State Scientific Research and Test Institute of Military Medicine, Ministry for Defense of the Russian Federation
Email: gniiivm_15@mil.ru
junior researcher at the Research Department
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