Применение наночастиц серебра в медицине: плюсы и минусы. Преимущества композитов наночастиц серебра с органическими антибактериальными субстанциями и биосовместимыми полимерами

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Аннотация

Развитие резистентности бактерий к применяемым в клинической практике препаратам является серьезной проблемой современной медицины. Наночастицы в настоящее время широко используются в различных отраслях промышленности, а также в медицине. Антибактериальный потенциал наночастиц серебра обширен и распространяется на грамотрицательные и грамположительные бактерии, включая мультирезистентные штаммы, в том числе в составе бактериальных биопленок. Установлено, что наночастицы серебра имеют множественные мишени антимикробного действия, вследствие чего развитие микробной резистентности к ним затруднено. Кроме того, для серебра описаны другие виды биологической активности: ранозаживляющая, противовоспалительная, противоопухолевая. Однако, несмотря на несомненные достоинства этих наноматериалов, до сих пор остаются и проблемы с их применением в медицине, связанные с некоторым нежелательным влиянием на живые объекты. Столь разнообразные биологические свойства, а также потенциальная токсичность наночастиц серебра определяются размером и формой наночастиц, способом их синтеза и видом стабилизирующего агента. В данном обзоре приводится информация по способам модификации наночастиц серебра антибактериальными соединениями, такими как антибиотики, антимикробные пептиды, которые демонстрируют синергические и аддитивные воздействия против патогенных бактерий при использовании в комбинации с наночастицами, а при создании комплексов повышают антимикробную активность и обеспечивают стабильность наночастиц. Поэтому композиты наночастиц серебра с органическими антибактериальными препаратами и биосовместимыми полимерами могут рассматриваться как перспективная основа для создания новых эффективных антибактериальных препаратов, лишенных нежелательных свойств.

Об авторах

Елизавета Васильевна Владимирова

Институт экспериментальной медицины

Email: vladymyrovaliza18@mail.ru
ORCID iD: 0000-0002-6576-9844
SPIN-код: 8068-4141
Россия, Санкт-Петербург

Ольга Валерьевна Шамова

Институт экспериментальной медицины

Автор, ответственный за переписку.
Email: oshamova@yandex.ru
ORCID iD: 0000-0002-5168-2801
SPIN-код: 2913-4726

д-р биол. наук, чл.-корр. РАН

Россия, Санкт-Петербург

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