头颈部恶性肿瘤计算机断层扫描的优先放射组学分析参数：系统综述

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论证。放射组学是现代放射治疗诊断中最新、最有前途的领域。使用这种方法对头颈部恶性肿瘤进行检查的数量每年都在增加。我们对基于计算机断层扫描的头颈部恶性肿瘤最新出版物（2021-2023 年）进行了系统综述。

目的是系统整理通过计算机断层扫描检测到的头颈部癌症的放射组学分析参数数据。

材料和方法。这些文章在 PubMed 数据库中进行了检索。我们提取了所选文章的基线特征，并使用 RQS 2.0 和修改后的 QUADAS-CAD 问卷对其质量进行了评估。我们评估了不同研究中预后模型所选放射组学参数的可重复性水平。我们选择了 11 篇文章进行审查。在大多数情况下，由于人口统计参数和病理学水平的取样不平衡，系统误差的风险很高。

结果。在评估放射组学的质量时，所分析文章的得分范围从最高可能得分的 19.44% 到 50.00% 不等。导致研究质量下降的主要问题是研究结果缺乏外部验证（占所分析文章的 73%），以及研究数据无法获取或缺乏透明度（占 82%）。由于所使用的图像采集和后处理技术种类繁多，以及对放射组学参数的提取和统计处理，不同研究之间放射组学参数的可重复性很低。

结论。讨论将该方法引入临床实践的基本稳定放射组学参数分配的必要性，这只有在放射组学方法标准化和建立开放的放射组学数据库的情况下才能实现。

作者简介

Yuriy A. Vasilev

Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies

Email: npcmr@zdrav.mos.ru
ORCID iD: 0000-0002-0208-5218
SPIN 代码: 4458-5608

MD, Cand. Sci. (Medicine)

俄罗斯联邦, Moscow

Olga G. Nanova

Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies

编辑信件的主要联系方式.
Email: NanovaOG@zdrav.mos.ru
ORCID iD: 0000-0001-8886-3684
SPIN 代码: 6135-4872

Cand. Sci. (Biology)

俄罗斯联邦, Moscow

Ivan A. Blokhin

Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies

Email: i.blokhin@npcmr.ru
ORCID iD: 0000-0002-2681-9378
SPIN 代码: 3306-1387
俄罗斯联邦, Moscow

Roman V. Reshetnikov

Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies

Email: reshetnikov@fbb.msu.ru
ORCID iD: 0000-0002-9661-0254
SPIN 代码: 8592-0558

Cand. Sci. (Physics and Mathematics)

俄罗斯联邦, Moscow

Anton V. Vladzymyrskyy

Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies

Email: npcmr@zdrav.mos.ru
ORCID iD: 0000-0002-2990-7736
SPIN 代码: 3602-7120

MD, Dr. Sci. (Medicine), Professor

俄罗斯联邦, Moscow

Olga V. Omelyanskaya

Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies

Email: o.omelyanskaya@npcmr.ru
ORCID iD: 0000-0002-0245-4431
SPIN 代码: 8948-6152
俄罗斯联邦, Moscow

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补充文件

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1. JATS XML
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2. Fig. 1. Flow chart of systematic literature search. MRI — magnetic resonance imaging, US — ultrasound diagnostics

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3. Supplement 1. Table 1. Basic characteristics of articles
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4. SUPPLEMENT 2. Table 2. Assessment of the quality of radiomics according to RQS-2.0
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