Tissue sampling and histopathological limitations in esophageal cancer
- Authors: Akhmedzyanova D.A.1, Yutsevich O.K.2, Reshetnikov R.V.1, Tashchyаn O.V.3, Pirogov S.S.2, Mazurova M.P.2, Volchenko N.N.2, Kamalov A.K.2, Shumskaya Y.F.1, Mnatsakanyan M.G.3
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Affiliations:
- Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies
- P.A. Herzen Moscow Oncology Research Institute, Branch, National Medical Research Radiological Center
- The First Sechenov Moscow State Medical University
- Issue: Vol 4, No 4 (2023)
- Pages: 633-642
- Section: Case reports
- URL: https://journals.rcsi.science/DD/article/view/262990
- DOI: https://doi.org/10.17816/DD561354
- ID: 262990
Cite item
Abstract
Esophageal adenocarcinoma is a common gastrointestinal cancer. Esophagogastroduodenoscopy with biopsy and immunohistochemistry are used to detect the neoplasm at an early stage. Definitive diagnosis requires not only highly specialized equipment but also the skills of the endoscopist and pathologist. We report the case of a 35-year-old man with progressive dysphagia caused by gastroesophageal cancer. Numerous esophagogastroduodenoscopy studies, computed tomography, and barium X-ray swallow revealed an extensive esophageal lesion; however, pathomorphologic examinations did not confirm malignancy within a year. Histological studies showed pyloric gland adenoma and adenoma from parietal or oncocytic cells with high-grade dysplasia. Esophagogastroduodenoscopy with targeted biopsy at a specialized center confirmed the tumor malignancy. This clinical case demonstrates the importance of summing clinical symptoms and using additional instrumental methods to make a definitive diagnosis if biopsy results are ambiguous.
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##article.viewOnOriginalSite##About the authors
Dina A. Akhmedzyanova
Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies
Author for correspondence.
Email: AkhmedzyanovaDA@zdrav.mos.ru
ORCID iD: 0000-0001-7705-9754
SPIN-code: 6983-5991
Scopus Author ID: 58104960900
Russian Federation, Moscow
Olga K. Yutsevich
P.A. Herzen Moscow Oncology Research Institute, Branch, National Medical Research Radiological Center
Email: o.yutsevitch@yandex.ru
ORCID iD: 0000-0002-3860-9853
Russian Federation, Moscow
Roman V. Reshetnikov
Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies
Email: r.reshetnikov@npcmr.ru
ORCID iD: 0000-0002-9661-0254
SPIN-code: 8592-0558
Cand. Sci. (Phys.-Math.)
Russian Federation, MoscowOlga V. Tashchyаn
The First Sechenov Moscow State Medical University
Email: olgatash1@rambler.ru
ORCID iD: 0000-0001-6759-6820
SPIN-code: 3658-1120
MD, Cand. Sci. (Med.)
Russian Federation, MoscowSergey S. Pirogov
P.A. Herzen Moscow Oncology Research Institute, Branch, National Medical Research Radiological Center
Email: pirogov@mail.ru
ORCID iD: 0000-0002-8101-2155
SPIN-code: 7812-5502
MD, Dr. Sci. (Med.)
Russian Federation, MoscowMaria P. Mazurova
P.A. Herzen Moscow Oncology Research Institute, Branch, National Medical Research Radiological Center
Email: mnioi_morphology@mail.ru
ORCID iD: 0000-0002-4873-4455
SPIN-code: 4455-3055
MD, Cand. Sci. (Med.)
Russian Federation, MoscowNadezhda N. Volchenko
P.A. Herzen Moscow Oncology Research Institute, Branch, National Medical Research Radiological Center
Email: mnioi_morphology@mail.ru
ORCID iD: 0000-0003-0421-4172
MD, Dr. Sci. (Med.), Professor
Russian Federation, MoscowAziz K. Kamalov
P.A. Herzen Moscow Oncology Research Institute, Branch, National Medical Research Radiological Center
Email: kak6768@mail.ru
ORCID iD: 0000-0001-7376-6056
SPIN-code: 1671-1600
Russian Federation, Moscow
Yuliya F. Shumskaya
Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies
Email: ShumskayaYF@zdrav.mos.ru
ORCID iD: 0000-0002-8521-4045
SPIN-code: 3164-5518
Russian Federation, Moscow
Marina G. Mnatsakanyan
The First Sechenov Moscow State Medical University
Email: mnatsakanyan08@mail.ru
ORCID iD: 0000-0001-9337-7453
SPIN-code: 2015-1822
MD, Dr. Sci. (Med.), Professor
Russian Federation, MoscowReferences
- Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424. doi: 10.3322/caac.21492
- McColl KEL. What is causing the rising incidence of esophageal adenocarcinoma in the West and will it also happen in the East? J Gastroenterol. 2019;54(8):669–673. doi: 10.1007/s00535-019-01593-7
- Joseph A, Raja S, Kamath S, et al. Esophageal adenocarcinoma: A dire need for early detection and treatment. Cleve Clin J Med. 2022;89(5):269–279. doi: 10.3949/ccjm.89a.21053
- Uhlenhopp DJ, Then EO, Sunkara T, Gaduputi V. Epidemiology of esophageal cancer: update in global trends, etiology and risk factors. Clin J Gastroenterol. 2020;13(6):1010–1021. doi: 10.1007/s12328-020-01237-x
- Zhang HY, Spechler SJ, Souza RF. Esophageal adenocarcinoma arising in Barrett esophagus. Cancer Lett. 2009;275(2):170–177. doi: 10.1016/j.canlet.2008.07.006
- Deng HY, Alai G, Luo J, et al. Cancerous esophageal stenosis before treatment was significantly correlated to poor prognosis of patients with esophageal cancer: a meta-analysis. J Thorac Dis. 2018;10(7):4212–4219. doi: 10.21037/jtd.2018.06.89
- Sillah K, Pritchard SA, Watkins GR, et al. The degree of circumferential tumour involvement as a prognostic factor in oesophageal cancer. Eur J Cardiothorac Surg. 2009;36(2):368–373. doi: 10.1016/j.ejcts.2008.12.052
- Deng HY, Li G, Luo J. Does oesophageal stenosis have any impact on survival of oesophageal cancer patients? Interact Cardiovasc Thorac Surg. 2018;27(3):384–386. doi: 10.1093/icvts/ivy095
- Knight WRC, McEwen R, Byrne BE, et al. Endoscopic tumour morphology impacts survival in adenocarcinoma of the oesophagus. Eur J Surg Oncol. 2020;46(12):2257–2261. doi: 10.1016/j.ejso.2020.07.003
- Morozov SP, editor. I-74 Informativeness of radial diagnostics methods in various pathological conditions of the organism. Section 2: Diagnostics of pathological conditions and diseases of the gastrointestinal tract. Moscow; 2018. (In Russ).
- Ishihara R, Goda K, Oyama T. Endoscopic diagnosis and treatment of esophageal adenocarcinoma: introduction of Japan Esophageal Society classification of Barrett’s esophagus. J Gastroenterol. 2019;54(1):1–9. doi: 10.1007/s00535-018-1491-x
- Zagajnova EV, Zagajnov VE, Gladkova ND, et al. Optical coherence tomography in surgical treatment of esophageal cancer. Grekov’s Bulletin of Surgery. 2007;166(2):22–26.
- Davydov MI, Ter-Ovanesov MD, Stilidi IS, et al. Barrett’s esophagus: from theoretical foundations to practical recommendations. Practical oncology. 2003;4(2):109–119. (In Russ).
- Barber MS, Aronson JK, von Schoen-Angerer T, et al. CARe guidelines for case reports: explanation and elaboration document. Translation into Russian. Digital Diagnostics. 2022;3(1):16–42. doi: 10.17816/DD105291
- Wani S, Rubenstein JH, Vieth M, Bergman J. Diagnosis and Management of Low-Grade Dysplasia in Barrett’s Esophagus: Expert Review From the Clinical Practice Updates Committee of the American Gastroenterological Association. Gastroenterology. 2016;151(5):822–835. doi: 10.1053/j.gastro.2016.09.040
- di Pietro M, Canto MI, Fitzgerald RC. Endoscopic Management of Early Adenocarcinoma and Squamous Cell Carcinoma of the Esophagus: Screening, Diagnosis, and Therapy. Gastroenterology. 2018;154(2):421–436. doi: 10.1053/j.gastro.2017.07.041
- Winiker M, Mantziari S, Figueiredo SG, et al. Accuracy of preoperative staging for a priori resectable esophageal cancer. Dis Esophagus. 2018;31(1):1–6. doi: 10.1093/dote/dox113
- Elsadek HM, Radwan MM. Diagnostic Accuracy of Mucosal Biopsy versus Endoscopic Mucosal Resection in Barrett’s Esophagus and Related Superficial Lesions. Int Sch Res Notices. 2015;2015. doi: 10.1155/2015/735807
- Tryakin AA, Besova NS, Volkov NM, et al. Practice guidelines for drug treatment of esophageal and gastroesophageal junction cancers. Malignant tumours (Zlokačestvennye opuholi). 2021;11(3S2-1):299–313. (In Russ). doi: 10.18027/2224-5057-2021-11-3s2-20
- Ajani JA, D’Amico TA, Bentrem DJ, et al. Esophageal and Esophagogastric Junction Cancers, Version 2.2023, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2023;21(4):393–422. doi: 10.6004/jnccn.2023.0019
- Ormsby AH, Petras RE, Henricks WH, et al. Observer variation in the diagnosis of superficial oesophageal adenocarcinoma. Gut. 2002;51(5):671–676. doi: 10.1136/gut.51.5.671