PRPF19 mRNA encodes a small open reading frame that is important for viability of human cells
- Авторлар: Shepelev N.1,2, Kurochkina А.2, Dontsova О.1,3,4, Rubtsova M.1,2
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Мекемелер:
- Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
- Lomonosov Moscow State University
- A. N. Belozersky Institute of Physico-Chemical BiologyLomonosov Moscow State University
- Skolkovo Institute of Science and Technology
- Шығарылым: Том 515, № 1 (2024)
- Беттер: 37-44
- Бөлім: Articles
- URL: https://journals.rcsi.science/2686-7389/article/view/262823
- DOI: https://doi.org/10.31857/S2686738924020079
- EDN: https://elibrary.ru/WFODRJ
- ID: 262823
Дәйексөз келтіру
Аннотация
High-throughput ribosome profiling demonstrated the translation of thousands small open reading frames located in the 5′ untranslated regions of messenger RNAs (upstream ORFs). Upstream ORF can both perform a regulatory function by influencing the translation of the downstream main ORF, and encode a small functional protein or microprotein. In this work, we showed that the 5′ untranslated region of the PRPF19 mRNA encodes an upstream ORF that is translated in human cells. Inactivation of this upstream ORF reduces the viability of human cells.
Негізгі сөздер
Толық мәтін
Авторлар туралы
N. Shepelev
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences; Lomonosov Moscow State University
Хат алмасуға жауапты Автор.
Email: mprubtsova@gmail.com
Department of Chemistry
Ресей, Moscow; MoscowА. Kurochkina
Lomonosov Moscow State University
Email: mprubtsova@gmail.com
Department of Chemistry
Ресей, MoscowО. Dontsova
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences; A. N. Belozersky Institute of Physico-Chemical BiologyLomonosov Moscow State University; Skolkovo Institute of Science and Technology
Email: mprubtsova@gmail.com
Academician, Department of Chemistry, Center for Molecular and Cellular Biology
Ресей, Moscow; Moscow; Moscow; MoscowM. Rubtsova
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences; Lomonosov Moscow State University
Email: mprubtsova@gmail.com
Department of Chemistry
Ресей, Moscow; MoscowӘдебиет тізімі
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