MORPHOFUNCTIONAL AND MOLECULAR CHANGES IN PLACENTA AND PERIPHERAL BLOOD IN PREECLAMPSIA AND GESTATIONAL DIABETES MELITUS

K. A. Artemieva; Артемьева К. А.; Yu. V. Stepanova; Степанова Ю. В.; I. I. Stepanova; Степанова И. И.; M. V. Shamarakovа; Шамаракова М. В.; N. B. Tikhonova; Тихонова Н. Б.; N. V. Nizyaeva; Низяева Н. В.; S. G. Tsakhilova; Цахилова С. Г.; L. M. Mikhaleva; Михалева Л. М.

doi:10.31857/S2686738923600553

MORPHOFUNCTIONAL AND MOLECULAR CHANGES IN PLACENTA AND PERIPHERAL BLOOD IN PREECLAMPSIA AND GESTATIONAL DIABETES MELITUS

Авторлар: Artemieva K.¹, Stepanova Y.², Stepanova I.¹, Shamarakovа M.³, Tikhonova N.¹, Nizyaeva N.¹, Tsakhilova S.², Mikhaleva L.¹
Мекемелер:
1. “A.P. Avtsyn research institute of human morphology of Petrovsky National Research Centre of Surgery”
2. Evdokimov Moscow State University and Dentistry
3. SBHI of Moscow “City Clinical Hospital named after S.S. Yudin” of the Healthcare Department of Moscow
Шығарылым: Том 513, № 1 (2023)
Беттер: 555-563
Бөлім: Articles
URL: https://journals.rcsi.science/2686-7389/article/view/244368
DOI: https://doi.org/10.31857/S2686738923600553
EDN: https://elibrary.ru/GPFMGI
ID: 244368

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Статистика

Аннотация

Gestational diabetes mellitus (GDM) and preeclampsia (PE) are common pregnancy complications with similar risk factors. Although GDM is associated with PE, the exact mechanism underlying the association of these diseases is unclear. The aim of the work: to study morphofunctional and molecular changes in the placenta and peripheral blood both in PE and GDM. In the study, we evaluated local and systemic changes in the production of several placental proteins, markers of inflammation and metabolic disorders. Changes in villi expression of placental lactogen, trophoblastic β1-glycoprotein, placental alpha-1-microglobulin, and proteinase3 were noted in the groups of complicated pregnancies. The present study shows the similarity of the pathogenic mechanisms underlying PE and GDM.

Негізгі сөздер

pregnancy, preeclampsia, gestational diabetes mellitus, placental proteins, inflammation

Әдебиет тізімі

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