Technologies and Perspectives of Liposomal Drug Application in Clinical Practice

Resumo

In this article the results from studies of liposomes with the inclusion of active pharmacological substances (irinotecan, oxaliplatin, cytochrome C, doxorubicin, quercetine, etc.) in lipid nanoparticles are introduced. The key techniques of adding substances to liposomes are observed: the lipid-film method and the gradient and chemical-bond methods. The main conditions for the inclusion of drugs in liposomes are presented. Questions of determining the inclusion in liposomes and the synthesis and control of the liposomal drugs are discussed. The synthesized drugs are currently undergoing preclinical and clinical trials. Some of the proposed drugs have already been registered and have been used in medical practice for more than 25 years.